Cargando…

Clinicopathological Features and Prognosis Analysis of Primary Bile Duct and Ampullary Neuroendocrine Neoplasms: A Population-Based Study from 1975 to 2016

Background: The main purpose of this study is to analyze the clinicopathological features and prognosis factors of bile duct and ampullary neuroendocrine neoplasms (NENs). Methods: The relevant data were collected from the SEER database from 1975 to 2016. The Kaplan–Meier curve and Cox model were us...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yijun, Hua, Rui, He, Jianjun, Zhang, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858302/
https://www.ncbi.nlm.nih.gov/pubmed/36661685
http://dx.doi.org/10.3390/curroncol30010036
_version_ 1784874065494802432
author Li, Yijun
Hua, Rui
He, Jianjun
Zhang, Huimin
author_facet Li, Yijun
Hua, Rui
He, Jianjun
Zhang, Huimin
author_sort Li, Yijun
collection PubMed
description Background: The main purpose of this study is to analyze the clinicopathological features and prognosis factors of bile duct and ampullary neuroendocrine neoplasms (NENs). Methods: The relevant data were collected from the SEER database from 1975 to 2016. The Kaplan–Meier curve and Cox model were used for survival analysis. The nomogram was drawn to predict the survival rate. The calibration, discrimination and clinical utility of the nomogram were evaluated by calibration curve, the concordance index (C-index) and decision curve analysis (DCA). Results: A total of 340 cases were included in our research. According to Kaplan–Meier analysis, 1-year, 3-year and 5-year of overall survival (OS) were 77.3%, 61.9% and 58.4%, while 1-year, 3-year and 5-year of the disease-specific survival (DSS) were 82.7%, 69.3% and 66.9%, respectively. The multivariable analysis results showed that age, histological grade, SEER stage and surgery were independent predictors for either OS or DSS. The calibration curve and the C-index value indicated that the nomogram was well calibrated and had good discrimination. DCA showed that the model had ideal net benefits. Conclusions: The age, histological grade, SEER stage and surgery were identified as independent prognostic variables for OS and DSS. After verification, nomogram has good predictive ability and clinical application value.
format Online
Article
Text
id pubmed-9858302
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98583022023-01-21 Clinicopathological Features and Prognosis Analysis of Primary Bile Duct and Ampullary Neuroendocrine Neoplasms: A Population-Based Study from 1975 to 2016 Li, Yijun Hua, Rui He, Jianjun Zhang, Huimin Curr Oncol Article Background: The main purpose of this study is to analyze the clinicopathological features and prognosis factors of bile duct and ampullary neuroendocrine neoplasms (NENs). Methods: The relevant data were collected from the SEER database from 1975 to 2016. The Kaplan–Meier curve and Cox model were used for survival analysis. The nomogram was drawn to predict the survival rate. The calibration, discrimination and clinical utility of the nomogram were evaluated by calibration curve, the concordance index (C-index) and decision curve analysis (DCA). Results: A total of 340 cases were included in our research. According to Kaplan–Meier analysis, 1-year, 3-year and 5-year of overall survival (OS) were 77.3%, 61.9% and 58.4%, while 1-year, 3-year and 5-year of the disease-specific survival (DSS) were 82.7%, 69.3% and 66.9%, respectively. The multivariable analysis results showed that age, histological grade, SEER stage and surgery were independent predictors for either OS or DSS. The calibration curve and the C-index value indicated that the nomogram was well calibrated and had good discrimination. DCA showed that the model had ideal net benefits. Conclusions: The age, histological grade, SEER stage and surgery were identified as independent prognostic variables for OS and DSS. After verification, nomogram has good predictive ability and clinical application value. MDPI 2022-12-29 /pmc/articles/PMC9858302/ /pubmed/36661685 http://dx.doi.org/10.3390/curroncol30010036 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Yijun
Hua, Rui
He, Jianjun
Zhang, Huimin
Clinicopathological Features and Prognosis Analysis of Primary Bile Duct and Ampullary Neuroendocrine Neoplasms: A Population-Based Study from 1975 to 2016
title Clinicopathological Features and Prognosis Analysis of Primary Bile Duct and Ampullary Neuroendocrine Neoplasms: A Population-Based Study from 1975 to 2016
title_full Clinicopathological Features and Prognosis Analysis of Primary Bile Duct and Ampullary Neuroendocrine Neoplasms: A Population-Based Study from 1975 to 2016
title_fullStr Clinicopathological Features and Prognosis Analysis of Primary Bile Duct and Ampullary Neuroendocrine Neoplasms: A Population-Based Study from 1975 to 2016
title_full_unstemmed Clinicopathological Features and Prognosis Analysis of Primary Bile Duct and Ampullary Neuroendocrine Neoplasms: A Population-Based Study from 1975 to 2016
title_short Clinicopathological Features and Prognosis Analysis of Primary Bile Duct and Ampullary Neuroendocrine Neoplasms: A Population-Based Study from 1975 to 2016
title_sort clinicopathological features and prognosis analysis of primary bile duct and ampullary neuroendocrine neoplasms: a population-based study from 1975 to 2016
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858302/
https://www.ncbi.nlm.nih.gov/pubmed/36661685
http://dx.doi.org/10.3390/curroncol30010036
work_keys_str_mv AT liyijun clinicopathologicalfeaturesandprognosisanalysisofprimarybileductandampullaryneuroendocrineneoplasmsapopulationbasedstudyfrom1975to2016
AT huarui clinicopathologicalfeaturesandprognosisanalysisofprimarybileductandampullaryneuroendocrineneoplasmsapopulationbasedstudyfrom1975to2016
AT hejianjun clinicopathologicalfeaturesandprognosisanalysisofprimarybileductandampullaryneuroendocrineneoplasmsapopulationbasedstudyfrom1975to2016
AT zhanghuimin clinicopathologicalfeaturesandprognosisanalysisofprimarybileductandampullaryneuroendocrineneoplasmsapopulationbasedstudyfrom1975to2016