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High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice
Circadian, metabolic, and reproductive systems are inter-regulated. Excessive fatness and circadian disruption alter normal physiology and the endocrine milieu, including cortisol, the primary stress hormone. Our aim was to determine the effect feeding a high fat diet to female ICR mice had on diurn...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858401/ https://www.ncbi.nlm.nih.gov/pubmed/36662804 http://dx.doi.org/10.1371/journal.pone.0279209 |
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author | Teeple, Kelsey Rajput, Prabha Gonzalez, Maria Han-Hallett, Yu Fernández-Juricic, Esteban Casey, Theresa |
author_facet | Teeple, Kelsey Rajput, Prabha Gonzalez, Maria Han-Hallett, Yu Fernández-Juricic, Esteban Casey, Theresa |
author_sort | Teeple, Kelsey |
collection | PubMed |
description | Circadian, metabolic, and reproductive systems are inter-regulated. Excessive fatness and circadian disruption alter normal physiology and the endocrine milieu, including cortisol, the primary stress hormone. Our aim was to determine the effect feeding a high fat diet to female ICR mice had on diurnal feeding pattern, weight gain, body composition, hair corticosterone levels and circadian patterns of fecal corticosterone. Prepubertal (~35d of age) ICR mice were assigned to control (CON; 10% fat) or high fat (HF; 60% fat) diet and fed for 4 wk to achieve obesity under 12h light and 12h of dark. Feed intake was measured twice daily to determine diurnal intake. Mice were weighed weekly. After 4 wk on diets hair was collected to measure corticosterone, crown-rump length was measured to calculate body mass index (BMI), and body composition was measured with EchoMRI to determine percent fat. HF mice weighed more (P<0.05) after week two, BMI and percent body fat was greater (P<0.05) in HF than CON at the end of wk 4. HF mice consumed more during the day (P<0.05) than CON mice after 1 week on diets. Hair corticosterone was higher in HF mice than in CON (P<0.05). Fecal circadian sampling over 48hr demonstrated that HF mice had elevated basal corticosterone, attenuated circadian rhythms, and a shift in amplitude. High fat feeding for diet induced obesity alters circadian eating pattern and corticosterone rhythms, indicating a need to consider the impact of circadian system disruption on reproductive competence. |
format | Online Article Text |
id | pubmed-9858401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-98584012023-01-21 High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice Teeple, Kelsey Rajput, Prabha Gonzalez, Maria Han-Hallett, Yu Fernández-Juricic, Esteban Casey, Theresa PLoS One Research Article Circadian, metabolic, and reproductive systems are inter-regulated. Excessive fatness and circadian disruption alter normal physiology and the endocrine milieu, including cortisol, the primary stress hormone. Our aim was to determine the effect feeding a high fat diet to female ICR mice had on diurnal feeding pattern, weight gain, body composition, hair corticosterone levels and circadian patterns of fecal corticosterone. Prepubertal (~35d of age) ICR mice were assigned to control (CON; 10% fat) or high fat (HF; 60% fat) diet and fed for 4 wk to achieve obesity under 12h light and 12h of dark. Feed intake was measured twice daily to determine diurnal intake. Mice were weighed weekly. After 4 wk on diets hair was collected to measure corticosterone, crown-rump length was measured to calculate body mass index (BMI), and body composition was measured with EchoMRI to determine percent fat. HF mice weighed more (P<0.05) after week two, BMI and percent body fat was greater (P<0.05) in HF than CON at the end of wk 4. HF mice consumed more during the day (P<0.05) than CON mice after 1 week on diets. Hair corticosterone was higher in HF mice than in CON (P<0.05). Fecal circadian sampling over 48hr demonstrated that HF mice had elevated basal corticosterone, attenuated circadian rhythms, and a shift in amplitude. High fat feeding for diet induced obesity alters circadian eating pattern and corticosterone rhythms, indicating a need to consider the impact of circadian system disruption on reproductive competence. Public Library of Science 2023-01-20 /pmc/articles/PMC9858401/ /pubmed/36662804 http://dx.doi.org/10.1371/journal.pone.0279209 Text en © 2023 Teeple et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Teeple, Kelsey Rajput, Prabha Gonzalez, Maria Han-Hallett, Yu Fernández-Juricic, Esteban Casey, Theresa High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice |
title | High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice |
title_full | High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice |
title_fullStr | High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice |
title_full_unstemmed | High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice |
title_short | High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice |
title_sort | high fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female icr mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858401/ https://www.ncbi.nlm.nih.gov/pubmed/36662804 http://dx.doi.org/10.1371/journal.pone.0279209 |
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