Design, synthesis and biological evaluation of 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives as CDK inhibitors

To explore the potential use of CDK inhibitors in pancreatic ductal adenocarcinoma (PDAC) therapy, a series of novel 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives was designed, synthesised, and investigated for inhibition on both CDK kinase activity and cellular proliferation of...

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Detalles Bibliográficos
Autores principales: Yang, Bo, Quan, Yanni, Zhao, Wuli, Ji, Yingjie, Yang, Xiaotang, Li, Jianrui, Li, Yi, Liu, Xiujun, Wang, Ying, Li, Yanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858427/
https://www.ncbi.nlm.nih.gov/pubmed/36656085
http://dx.doi.org/10.1080/14756366.2023.2169282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858427/
https://www.ncbi.nlm.nih.gov/pubmed/36656085
http://dx.doi.org/10.1080/14756366.2023.2169282

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