An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors

Conflicting evidence exists on the association between consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and symptomatic worsening of inflammatory bowel disease (IBD). We hypothesized that the heterogeneous prevalence of pathobionts [e.g., adherent-invasive Escherichia coli (AIEC)], migh...

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Detalles Bibliográficos
Autores principales: Singh, Raminder, Rossini, Valerio, Stockdale, Stephen R., Saiz-Gonzalo, Gonzalo, Hanrahan, Naomi, D’ Souza, Tanya, Clooney, Adam, Draper, Lorraine A., Hill, Colin, Nally, Ken, Shanahan, Fergus, Andersson-Engels, Stefan, Melgar, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858430/
https://www.ncbi.nlm.nih.gov/pubmed/36656595
http://dx.doi.org/10.1080/19490976.2022.2163838

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