Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa

Severe, early-onset photoreceptor (PR) degeneration associated with MERTK mutations is thought to result from failed phagocytosis by retinal pigment epithelium (RPE). Notwithstanding, the severity and onset of PR degeneration in mouse models of Mertk ablation are determined by the hypomorphic expres...

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Detalles Bibliográficos
Autores principales: Mercau, Maria E., Akalu, Yemsratch T., Mazzoni, Francesca, Gyimesi, Gavin, Alberto, Emily J., Kong, Yong, Hafler, Brian P., Finnemann, Silvia C., Rothlin, Carla V., Ghosh, Sourav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858494/
https://www.ncbi.nlm.nih.gov/pubmed/36662852
http://dx.doi.org/10.1126/sciadv.ade9459

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