A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy

Although literature suggests that resistance to TNF inhibitor (TNFi) therapy in patients with ulcerative colitis (UC) is partially linked to immune cell populations in the inflamed region, there is still substantial uncertainty underlying the relevant spatial context. Here, we used the highly multip...

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Detalles Bibliográficos
Autores principales: Mayer, Aaron T., Holman, Derek R., Sood, Anav, Tandon, Utkarsh, Bhate, Salil S., Bodapati, Sunil, Barlow, Graham L., Chang, Jeff, Black, Sarah, Crenshaw, Erica C., Koron, Alexander N., Streett, Sarah E., Gambhir, Sanjiv S., Sandborn, William J., Boland, Brigid S., Hastie, Trevor, Tibshirani, Robert, Chang, John T., Nolan, Garry P., Schürch, Christian M., Rogalla, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858501/
https://www.ncbi.nlm.nih.gov/pubmed/36662860
http://dx.doi.org/10.1126/sciadv.add1166

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