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Cullin-5 deficiency orchestrates the tumor microenvironment to promote mammary tumor development through CREB1-CCL2 signaling

Breast cancer–associated gene 1 (Brca1) deficiency induces the onset of breast cancer formation, accompanied with extensive genetic alterations. Here, we used both the sleeping beauty transposon mutagenesis system and CRISPR-Cas9–mediated genome-wide screening in mice to identify potential genetic a...

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Detalles Bibliográficos
Autores principales:	Chen, Si, Shao, Fangyuan, Zeng, Jianming, Guo, Sen, Wang, Lijian, Sun, Heng, Lei, Josh Haipeng, Lyu, Xueying, Gao, Shuai, Chen, Qiang, Miao, Kai, Xu, Xiaoling, Deng, Chu-Xia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858512/ https://www.ncbi.nlm.nih.gov/pubmed/36662868 http://dx.doi.org/10.1126/sciadv.abq1395

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