Cargando…

Successful Detection of the Characteristics of Tear Film Breakup Appearing Immediately after Eye Opening by Videokeratography with a Newly-Developed Indicator

Spot break (SB), a tear film breakup (TFBU) subtype seen in decreased wettability dry eye (DE), is characterized by a spot-like TFBU that appears immediately after eye opening. It is sometimes difficult to detect using currently available devices for evaluating non-invasive TFBU. The purpose of this...

Descripción completa

Detalles Bibliográficos
Autores principales: Yokoi, Norihiko, Kusada, Natsuki, Kato, Hiroaki, Furusawa, Yuki, Sotozono, Chie, Georgiev, Georgi As.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858532/
https://www.ncbi.nlm.nih.gov/pubmed/36673051
http://dx.doi.org/10.3390/diagnostics13020240
_version_ 1784874124646023168
author Yokoi, Norihiko
Kusada, Natsuki
Kato, Hiroaki
Furusawa, Yuki
Sotozono, Chie
Georgiev, Georgi As.
author_facet Yokoi, Norihiko
Kusada, Natsuki
Kato, Hiroaki
Furusawa, Yuki
Sotozono, Chie
Georgiev, Georgi As.
author_sort Yokoi, Norihiko
collection PubMed
description Spot break (SB), a tear film breakup (TFBU) subtype seen in decreased wettability dry eye (DE), is characterized by a spot-like TFBU that appears immediately after eye opening. It is sometimes difficult to detect using currently available devices for evaluating non-invasive TFBU. The purpose of this study was to investigate the effectiveness of using a newly developed videokeratography indicator for detecting SB. The study involved 44 eyes of 44 DE patients (21 eyes with SB (SB group) and 23 eyes with random break in which fluorescein breakup time was ≤ 5 s (s) (RB group)). All eyes were examined using videokeratography, with digital Meyer-ring images being obtained. By calculation of the degree of luminance blur on the cornea in the Meyer-ring images, termed ‘disturbance value’ (DV), DVs at 0 s (DV(0)]), 2 s (DV(2)), and 5 s (DV(5)) after eye opening, and the changes of DV between each time, were compared between the SB and RB groups. Results: No significant differences in DV(2) and DV(5) and the rate of change between DV(2) and DV(5) were found between the two groups. However, DV(0) and rate of change between DV(0) and DV(2) in the SB group were significantly greater (p < 0.001) than those in the RB group. SB characteristics were successfully detected by videokeratography using a new videokeratography DV indicator.
format Online
Article
Text
id pubmed-9858532
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98585322023-01-21 Successful Detection of the Characteristics of Tear Film Breakup Appearing Immediately after Eye Opening by Videokeratography with a Newly-Developed Indicator Yokoi, Norihiko Kusada, Natsuki Kato, Hiroaki Furusawa, Yuki Sotozono, Chie Georgiev, Georgi As. Diagnostics (Basel) Article Spot break (SB), a tear film breakup (TFBU) subtype seen in decreased wettability dry eye (DE), is characterized by a spot-like TFBU that appears immediately after eye opening. It is sometimes difficult to detect using currently available devices for evaluating non-invasive TFBU. The purpose of this study was to investigate the effectiveness of using a newly developed videokeratography indicator for detecting SB. The study involved 44 eyes of 44 DE patients (21 eyes with SB (SB group) and 23 eyes with random break in which fluorescein breakup time was ≤ 5 s (s) (RB group)). All eyes were examined using videokeratography, with digital Meyer-ring images being obtained. By calculation of the degree of luminance blur on the cornea in the Meyer-ring images, termed ‘disturbance value’ (DV), DVs at 0 s (DV(0)]), 2 s (DV(2)), and 5 s (DV(5)) after eye opening, and the changes of DV between each time, were compared between the SB and RB groups. Results: No significant differences in DV(2) and DV(5) and the rate of change between DV(2) and DV(5) were found between the two groups. However, DV(0) and rate of change between DV(0) and DV(2) in the SB group were significantly greater (p < 0.001) than those in the RB group. SB characteristics were successfully detected by videokeratography using a new videokeratography DV indicator. MDPI 2023-01-09 /pmc/articles/PMC9858532/ /pubmed/36673051 http://dx.doi.org/10.3390/diagnostics13020240 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yokoi, Norihiko
Kusada, Natsuki
Kato, Hiroaki
Furusawa, Yuki
Sotozono, Chie
Georgiev, Georgi As.
Successful Detection of the Characteristics of Tear Film Breakup Appearing Immediately after Eye Opening by Videokeratography with a Newly-Developed Indicator
title Successful Detection of the Characteristics of Tear Film Breakup Appearing Immediately after Eye Opening by Videokeratography with a Newly-Developed Indicator
title_full Successful Detection of the Characteristics of Tear Film Breakup Appearing Immediately after Eye Opening by Videokeratography with a Newly-Developed Indicator
title_fullStr Successful Detection of the Characteristics of Tear Film Breakup Appearing Immediately after Eye Opening by Videokeratography with a Newly-Developed Indicator
title_full_unstemmed Successful Detection of the Characteristics of Tear Film Breakup Appearing Immediately after Eye Opening by Videokeratography with a Newly-Developed Indicator
title_short Successful Detection of the Characteristics of Tear Film Breakup Appearing Immediately after Eye Opening by Videokeratography with a Newly-Developed Indicator
title_sort successful detection of the characteristics of tear film breakup appearing immediately after eye opening by videokeratography with a newly-developed indicator
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858532/
https://www.ncbi.nlm.nih.gov/pubmed/36673051
http://dx.doi.org/10.3390/diagnostics13020240
work_keys_str_mv AT yokoinorihiko successfuldetectionofthecharacteristicsoftearfilmbreakupappearingimmediatelyaftereyeopeningbyvideokeratographywithanewlydevelopedindicator
AT kusadanatsuki successfuldetectionofthecharacteristicsoftearfilmbreakupappearingimmediatelyaftereyeopeningbyvideokeratographywithanewlydevelopedindicator
AT katohiroaki successfuldetectionofthecharacteristicsoftearfilmbreakupappearingimmediatelyaftereyeopeningbyvideokeratographywithanewlydevelopedindicator
AT furusawayuki successfuldetectionofthecharacteristicsoftearfilmbreakupappearingimmediatelyaftereyeopeningbyvideokeratographywithanewlydevelopedindicator
AT sotozonochie successfuldetectionofthecharacteristicsoftearfilmbreakupappearingimmediatelyaftereyeopeningbyvideokeratographywithanewlydevelopedindicator
AT georgievgeorgias successfuldetectionofthecharacteristicsoftearfilmbreakupappearingimmediatelyaftereyeopeningbyvideokeratographywithanewlydevelopedindicator