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High Coverage Mitogenomes and Y-Chromosomal Typing Reveal Ancient Lineages in the Modern-Day Székely Population in Romania

Here we present 115 whole mitogenomes and 92 Y-chromosomal Short Tandem Repeat (STR) and Single Nucleotide Polymorphism (SNP) profiles from a Hungarian ethnic group, the Székelys (in Romanian: Secuii, in German: Sekler), living in southeast Transylvania (Romania). The Székelys can be traced back to...

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Autores principales: Borbély, Noémi, Székely, Orsolya, Szeifert, Bea, Gerber, Dániel, Máthé, István, Benkő, Elek, Mende, Balázs Gusztáv, Egyed, Balázs, Pamjav, Horolma, Szécsényi-Nagy, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858685/
https://www.ncbi.nlm.nih.gov/pubmed/36672874
http://dx.doi.org/10.3390/genes14010133
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author Borbély, Noémi
Székely, Orsolya
Szeifert, Bea
Gerber, Dániel
Máthé, István
Benkő, Elek
Mende, Balázs Gusztáv
Egyed, Balázs
Pamjav, Horolma
Szécsényi-Nagy, Anna
author_facet Borbély, Noémi
Székely, Orsolya
Szeifert, Bea
Gerber, Dániel
Máthé, István
Benkő, Elek
Mende, Balázs Gusztáv
Egyed, Balázs
Pamjav, Horolma
Szécsényi-Nagy, Anna
author_sort Borbély, Noémi
collection PubMed
description Here we present 115 whole mitogenomes and 92 Y-chromosomal Short Tandem Repeat (STR) and Single Nucleotide Polymorphism (SNP) profiles from a Hungarian ethnic group, the Székelys (in Romanian: Secuii, in German: Sekler), living in southeast Transylvania (Romania). The Székelys can be traced back to the 12th century in the region, and numerous scientific theories exist as to their origin. We carefully selected sample providers that had local ancestors inhabiting small villages in the area of Odorheiu Secuiesc/Székelyudvarhely in Romania. The results of our research and the reported data signify a qualitative leap compared to previous studies since it presents the first complete mitochondrial DNA sequences and Y-chromosomal profiles of 23 STRs from the region. We evaluated the results with population genetic and phylogenetic methods in the context of the modern and ancient populations that are either geographically or historically related to the Székelys. Our results demonstrate a predominantly local uniparental make-up of the population that also indicates limited admixture with neighboring populations. Phylogenetic analyses confirmed the presumed eastern origin of certain maternal (A, C, D) and paternal (Q, R1a) lineages, and, in some cases, they could also be linked to ancient DNA data from the Migration Period (5th–9th centuries AD) and Hungarian Conquest Period (10th century AD) populations.
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spelling pubmed-98586852023-01-21 High Coverage Mitogenomes and Y-Chromosomal Typing Reveal Ancient Lineages in the Modern-Day Székely Population in Romania Borbély, Noémi Székely, Orsolya Szeifert, Bea Gerber, Dániel Máthé, István Benkő, Elek Mende, Balázs Gusztáv Egyed, Balázs Pamjav, Horolma Szécsényi-Nagy, Anna Genes (Basel) Article Here we present 115 whole mitogenomes and 92 Y-chromosomal Short Tandem Repeat (STR) and Single Nucleotide Polymorphism (SNP) profiles from a Hungarian ethnic group, the Székelys (in Romanian: Secuii, in German: Sekler), living in southeast Transylvania (Romania). The Székelys can be traced back to the 12th century in the region, and numerous scientific theories exist as to their origin. We carefully selected sample providers that had local ancestors inhabiting small villages in the area of Odorheiu Secuiesc/Székelyudvarhely in Romania. The results of our research and the reported data signify a qualitative leap compared to previous studies since it presents the first complete mitochondrial DNA sequences and Y-chromosomal profiles of 23 STRs from the region. We evaluated the results with population genetic and phylogenetic methods in the context of the modern and ancient populations that are either geographically or historically related to the Székelys. Our results demonstrate a predominantly local uniparental make-up of the population that also indicates limited admixture with neighboring populations. Phylogenetic analyses confirmed the presumed eastern origin of certain maternal (A, C, D) and paternal (Q, R1a) lineages, and, in some cases, they could also be linked to ancient DNA data from the Migration Period (5th–9th centuries AD) and Hungarian Conquest Period (10th century AD) populations. MDPI 2023-01-03 /pmc/articles/PMC9858685/ /pubmed/36672874 http://dx.doi.org/10.3390/genes14010133 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Borbély, Noémi
Székely, Orsolya
Szeifert, Bea
Gerber, Dániel
Máthé, István
Benkő, Elek
Mende, Balázs Gusztáv
Egyed, Balázs
Pamjav, Horolma
Szécsényi-Nagy, Anna
High Coverage Mitogenomes and Y-Chromosomal Typing Reveal Ancient Lineages in the Modern-Day Székely Population in Romania
title High Coverage Mitogenomes and Y-Chromosomal Typing Reveal Ancient Lineages in the Modern-Day Székely Population in Romania
title_full High Coverage Mitogenomes and Y-Chromosomal Typing Reveal Ancient Lineages in the Modern-Day Székely Population in Romania
title_fullStr High Coverage Mitogenomes and Y-Chromosomal Typing Reveal Ancient Lineages in the Modern-Day Székely Population in Romania
title_full_unstemmed High Coverage Mitogenomes and Y-Chromosomal Typing Reveal Ancient Lineages in the Modern-Day Székely Population in Romania
title_short High Coverage Mitogenomes and Y-Chromosomal Typing Reveal Ancient Lineages in the Modern-Day Székely Population in Romania
title_sort high coverage mitogenomes and y-chromosomal typing reveal ancient lineages in the modern-day székely population in romania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858685/
https://www.ncbi.nlm.nih.gov/pubmed/36672874
http://dx.doi.org/10.3390/genes14010133
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