Cargando…

Pathogenicity of PKCγ Genetic Variants—Possible Function as a Non-Invasive Diagnostic Biomarker in Ovarian Cancer

Ovarian cancer has the highest mortality rate among gynecologic malignancies, owing to its misdiagnosis or late diagnosis. Identification of its genetic determinants could improve disease outcomes. Conventional Protein Kinase C-γ (PKCγ) dysregulation is reported in several cancers. Similarly, its va...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shahid, Kanza, Khan, Khushbukhat, Badshah, Yasmin, Mahmood Ashraf, Naeem, Hamid, Arslan, Trembley, Janeen H., Shabbir, Maria, Afsar, Tayyaba, Almajwal, Ali, Abusharha, Ali, Razak, Suhail
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858858/ https://www.ncbi.nlm.nih.gov/pubmed/36672978 http://dx.doi.org/10.3390/genes14010236

Ejemplares similares

Exploring the prognostic significance of PKCε variants in cervical cancer
por: Zafar, Sameen, et al.
Publicado: (2023)

Correction: Exploring the prognostic significance of PKCε variants in cervical cancer
por: Zafar, Sameen, et al.
Publicado: (2023)

Analyzing PKC Gamma (+ 19,506 A/G) polymorphism as a promising genetic marker for HCV-induced hepatocellular carcinoma
por: Abid, Fizzah, et al.
Publicado: (2022)

Investigating pathogenic SNP of PKCι in HCV-induced hepatocellular carcinoma
por: Khan, Naila, et al.
Publicado: (2023)

Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer
por: Khan, Khushbukhat, et al.
Publicado: (2023)

Investigation of UTR Variants by Computational Approaches Reveal Their Functional Significance in PRKCI Gene Regulation
por: Shah, Hania, et al.
Publicado: (2023)

Non-synonymous SNPs variants of PRKCG and its association with oncogenes predispose to hepatocellular carcinoma
por: Abid, Fizzah, et al.
Publicado: (2023)

Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatocellular carcinoma
por: Rehman, Areeba, et al.
Publicado: (2023)

Bioassay-guided isolation and characterization of lead antimicrobial compounds from Acacia hydaspica plant extract
por: Afsar, Tayyaba, et al.
Publicado: (2022)

Determining KLF14 tertiary structure and diagnostic significance in brain cancer progression
por: Zahra, Kainat, et al.
Publicado: (2022)

Association of CTLA-4 and IL-4 polymorphisms in viral induced liver cancer
por: Shabbir, Maria, et al.
Publicado: (2022)

Prevention of Testicular Damage by Indole Derivative MMINA via Upregulated StAR and CatSper Channels with Coincident Suppression of Oxidative Stress and Inflammation: In Silico and In Vivo Validation
por: Afsar, Tayyaba, et al.
Publicado: (2022)

PRKCE non-coding variants influence on transcription as well as translation of its gene
por: Khan, Khushbukhat, et al.
Publicado: (2022)

Tissue microarray profiling and integrative proteomics indicate the modulatory potential of Maytenus royleanus in inhibition of overexpressed TPD52 in prostate cancers
por: Shabbir, Maria, et al.
Publicado: (2021)

Predicting 3D Structure, Cross Talks, and Prognostic Significance of KLF9 in Cervical Cancer
por: Safi, Sadia, et al.
Publicado: (2022)

Sulindac acetohydrazide derivative attenuates against cisplatin induced organ damage by modulation of antioxidant and inflammatory signaling pathways
por: Razak, Suhail, et al.
Publicado: (2022)

Effect of Acacia hydaspica R. Parker extract on lipid peroxidation, antioxidant status, liver function test and histopathology in doxorubicin treated rats
por: Afsar, Tayyaba, et al.
Publicado: (2019)

Reversal of cisplatin triggered neurotoxicity by Acacia hydaspica ethyl acetate fraction via regulating brain acetylcholinesterase activity, DNA damage, and pro-inflammatory cytokines in the rodent model
por: Afsar, Tayyaba, et al.
Publicado: (2022)

Evaluating the protective potency of Acacia hydaspica R. Parker on histological and biochemical changes induced by Cisplatin in the cardiac tissue of rats
por: Afsar, Tayyaba, et al.
Publicado: (2019)

Correction to: Evaluating the protective potency of Acacia hydaspica R. Parker on histological and biochemical changes induced by Cisplatin in the cardiac tissue of rats
por: Afsar, Tayyaba, et al.
Publicado: (2020)

Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice
por: Shabbir, Maria, et al.
Publicado: (2020)

Analyzing the Differential Impact of Semen Preparation Methods on the Outcomes of Assisted Reproductive Techniques
por: Bibi, Riffat, et al.
Publicado: (2023)

Protecting Tear-Film Stability under Adverse Environmental Conditions Using a Mucomimetic with a Non-Newtonian Viscosity Agent
por: Abusharha, Ali, et al.
Publicado: (2023)

Evaluation of Therapeutic Capability of Emustil Drops against Tear Film Complications under Dry Environmental Conditions in Healthy Individuals
por: Abusharha, Ali, et al.
Publicado: (2023)

Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways
por: Afsar, Tayyaba, et al.
Publicado: (2016)

Molecular Screening of Bioactive Compounds of Garlic for Therapeutic Effects against COVID-19
por: Ashraf, Huma, et al.
Publicado: (2023)

Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats
por: Afsar, Tayyaba, et al.
Publicado: (2017)

Acacia hydaspica R. Parker ameliorates cisplatin induced oxidative stress, DNA damage and morphological alterations in rat pulmonary tissue
por: Afsar, Tayyaba, et al.
Publicado: (2018)

Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats
por: Afsar, Tayyaba, et al.
Publicado: (2017)

Anti-depressant and anxiolytic potential of Acacia hydaspica R. Parker aerial parts extract: Modulation of brain antioxidant enzyme status
por: Afsar, Tayyaba, et al.
Publicado: (2017)

Doxorubicin-induced alterations in kidney functioning, oxidative stress, DNA damage, and renal tissue morphology; Improvement by Acacia hydaspica tannin-rich ethyl acetate fraction
por: Afsar, Tayyaba, et al.
Publicado: (2020)

Correction to: Acacia hydaspica R. Parker ameliorates cisplatin induced oxidative stress, DNA damage and morphological alterations in rat pulmonary tissue
por: Afsar, Tayyaba, et al.
Publicado: (2019)

Impact of deleterious missense PRKCI variants on structural and functional dynamics of protein
por: Shah, Hania, et al.
Publicado: (2022)

Evaluation of different treatment modalities on the efficacy of hydroxypropyl Guar (HP-Guar) formulation on tear film stability (TFS) in subjects exposed to adverse environmental conditions
por: Abusharha, Ali, et al.
Publicado: (2023)

Growth inhibition and apoptosis in colorectal cancer cells induced by Vitamin D-Nanoemulsion (NVD): involvement of Wnt/β-catenin and other signal transduction pathways
por: Razak, Suhail, et al.
Publicado: (2019)

Acacia hydaspica R. Parker ethyl-acetate extract abrogates cisplatin-induced nephrotoxicity by targeting ROS and inflammatory cytokines
por: Afsar, Tayyaba, et al.
Publicado: (2021)

Ameliorating potency of Chenopodium album Linn. and vitamin C against mercuric chloride-induced oxidative stress in testes of Sprague Dawley rats
por: Jahan, Sarwat, et al.
Publicado: (2019)

Determination of Pleiotropic Effect of Warfarin in VKORC1 and CYP2C9 Genotypes in Patients With Heart Valve Replacement
por: Shafique, Huma, et al.
Publicado: (2022)

Effect of bisphenol F, an analog of bisphenol A, on the reproductive functions of male rats
por: Ullah, Asad, et al.
Publicado: (2019)

Chronic exposure of bisphenol S (BPS) affect hypothalamic-pituitary-testicular activities in adult male rats: possible in estrogenic mode of action
por: Ullah, Hizb, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_u3s97mri7udj689ah0s5ngggg2