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A Crossed Pure Agraphia by Graphemic Buffer Impairment following Right Orbito-Frontal Glioma Resection

Pure agraphias are caused by graphemic buffer damage. The graphemic buffer stores graphemic representations that handle the transition from spelling lexicon to writing or oral spellings. The authors report a case of a crossed pure agraphia, following the post-surgical removal of a right frontal low-...

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Autores principales: Arroyo-Anlló, Eva M., Pluchon, Claudette, Bouyer, Coline, Baudiffier, Vanessa, Stal, Veronique, Du Boisgueheneuc, Foucaud, Wager, Michel, Gil, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858865/
https://www.ncbi.nlm.nih.gov/pubmed/36674102
http://dx.doi.org/10.3390/ijerph20021346
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author Arroyo-Anlló, Eva M.
Pluchon, Claudette
Bouyer, Coline
Baudiffier, Vanessa
Stal, Veronique
Du Boisgueheneuc, Foucaud
Wager, Michel
Gil, Roger
author_facet Arroyo-Anlló, Eva M.
Pluchon, Claudette
Bouyer, Coline
Baudiffier, Vanessa
Stal, Veronique
Du Boisgueheneuc, Foucaud
Wager, Michel
Gil, Roger
author_sort Arroyo-Anlló, Eva M.
collection PubMed
description Pure agraphias are caused by graphemic buffer damage. The graphemic buffer stores graphemic representations that handle the transition from spelling lexicon to writing or oral spellings. The authors report a case of a crossed pure agraphia, following the post-surgical removal of a right frontal low-grade glioma in a right-handed French patient. He presented a pure agraphia displaying the features of a graphemic buffer impairment. Our patient only made spelling errors, whereas repetition and other oral language abilities remained perfect. We found a greater number of errors for longer stimuli, increased errors for the medially located graphemes, and agraphia for both words and non-words and error types, essentially consisting of omissions, substitutions, and letter transpositions. We also observed no significant effect of word frequency on spelling errors, but word length affected the rate of errors. The particularity of this case was linked to right frontal subcortical injuries in a right-handed subject. To our knowledge, it is the first report of a crossed pure agraphia caused by graphemic buffer impairment. Further studies are needed in order to analyse the role of subcortical structures, particularly the caudate nucleus in the graphemic buffer during writing tasks, as well as the participation of the non-dominant hemisphere in writing language.
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spelling pubmed-98588652023-01-21 A Crossed Pure Agraphia by Graphemic Buffer Impairment following Right Orbito-Frontal Glioma Resection Arroyo-Anlló, Eva M. Pluchon, Claudette Bouyer, Coline Baudiffier, Vanessa Stal, Veronique Du Boisgueheneuc, Foucaud Wager, Michel Gil, Roger Int J Environ Res Public Health Case Report Pure agraphias are caused by graphemic buffer damage. The graphemic buffer stores graphemic representations that handle the transition from spelling lexicon to writing or oral spellings. The authors report a case of a crossed pure agraphia, following the post-surgical removal of a right frontal low-grade glioma in a right-handed French patient. He presented a pure agraphia displaying the features of a graphemic buffer impairment. Our patient only made spelling errors, whereas repetition and other oral language abilities remained perfect. We found a greater number of errors for longer stimuli, increased errors for the medially located graphemes, and agraphia for both words and non-words and error types, essentially consisting of omissions, substitutions, and letter transpositions. We also observed no significant effect of word frequency on spelling errors, but word length affected the rate of errors. The particularity of this case was linked to right frontal subcortical injuries in a right-handed subject. To our knowledge, it is the first report of a crossed pure agraphia caused by graphemic buffer impairment. Further studies are needed in order to analyse the role of subcortical structures, particularly the caudate nucleus in the graphemic buffer during writing tasks, as well as the participation of the non-dominant hemisphere in writing language. MDPI 2023-01-11 /pmc/articles/PMC9858865/ /pubmed/36674102 http://dx.doi.org/10.3390/ijerph20021346 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Arroyo-Anlló, Eva M.
Pluchon, Claudette
Bouyer, Coline
Baudiffier, Vanessa
Stal, Veronique
Du Boisgueheneuc, Foucaud
Wager, Michel
Gil, Roger
A Crossed Pure Agraphia by Graphemic Buffer Impairment following Right Orbito-Frontal Glioma Resection
title A Crossed Pure Agraphia by Graphemic Buffer Impairment following Right Orbito-Frontal Glioma Resection
title_full A Crossed Pure Agraphia by Graphemic Buffer Impairment following Right Orbito-Frontal Glioma Resection
title_fullStr A Crossed Pure Agraphia by Graphemic Buffer Impairment following Right Orbito-Frontal Glioma Resection
title_full_unstemmed A Crossed Pure Agraphia by Graphemic Buffer Impairment following Right Orbito-Frontal Glioma Resection
title_short A Crossed Pure Agraphia by Graphemic Buffer Impairment following Right Orbito-Frontal Glioma Resection
title_sort crossed pure agraphia by graphemic buffer impairment following right orbito-frontal glioma resection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858865/
https://www.ncbi.nlm.nih.gov/pubmed/36674102
http://dx.doi.org/10.3390/ijerph20021346
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