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Comparison of Marker Effects and Breeding Values at Two Levels at THI for Milk Yield and Quality Traits in Brazilian Holstein Cows

Genomic tools can help in the selection of animals genetically resistant to heat stress, especially the genome-wide association studies (GWAS). The objective of this study was to compare the variance explained by SNPs and direct genomic breeding values (DGVs) at two levels of a temperature and humid...

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Autores principales: Carrara, Eula Regina, Dauria, Brayan Dias, Gervásio, Izally Carvalho, Silveira, Robson Mateus Freitas, Rovadoski, Gregori Alberto, Petrini, Juliana, Salvian, Mayara, Machado, Paulo Fernando, Mourão, Gerson Barreto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858941/
https://www.ncbi.nlm.nih.gov/pubmed/36672758
http://dx.doi.org/10.3390/genes14010017
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author Carrara, Eula Regina
Dauria, Brayan Dias
Gervásio, Izally Carvalho
Silveira, Robson Mateus Freitas
Rovadoski, Gregori Alberto
Petrini, Juliana
Salvian, Mayara
Machado, Paulo Fernando
Mourão, Gerson Barreto
author_facet Carrara, Eula Regina
Dauria, Brayan Dias
Gervásio, Izally Carvalho
Silveira, Robson Mateus Freitas
Rovadoski, Gregori Alberto
Petrini, Juliana
Salvian, Mayara
Machado, Paulo Fernando
Mourão, Gerson Barreto
author_sort Carrara, Eula Regina
collection PubMed
description Genomic tools can help in the selection of animals genetically resistant to heat stress, especially the genome-wide association studies (GWAS). The objective of this study was to compare the variance explained by SNPs and direct genomic breeding values (DGVs) at two levels of a temperature and humidity index (THI). Records of milk yield (MY), somatic cell score (SCS), and percentages of casein (CAS), saturated fatty acids (SFA), and unsaturated fatty acids (UFA) in milk from 1157 Holstein cows were used. Traditional breeding values (EBV) were determined in a previous study and used as pseudo-phenotypes. Two levels of THI (heat comfort zone and heat stress zone) were used as environments and were treated as “traits” in a bi-trait model. The GWAS was performed using the genomic best linear unbiased prediction (GBLUP) method. Considering the top 50 SNPs, a total of 36 SNPs were not common between environments, eight of which were located in gene regions related to the evaluated traits. Even for those SNPs that had differences in their explained variances between the two environments, the differences were very small. The animals showed virtually no rank order, with rank correlation values of 0.90, 0.88, 1.00, 0.88, and 0.97 for MY, CAS, SCS, SFA, and UFA, respectively. The small difference between the environments studied can be attributed to the small difference in the pseudo-phenotypes used between the environments, on-farm acclimation, the polygenic nature of the traits, and the THI values studied near the threshold between comfort and heat stress. It is recommended that future studies be conducted with a larger number of animals and at more extreme THI levels.
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spelling pubmed-98589412023-01-21 Comparison of Marker Effects and Breeding Values at Two Levels at THI for Milk Yield and Quality Traits in Brazilian Holstein Cows Carrara, Eula Regina Dauria, Brayan Dias Gervásio, Izally Carvalho Silveira, Robson Mateus Freitas Rovadoski, Gregori Alberto Petrini, Juliana Salvian, Mayara Machado, Paulo Fernando Mourão, Gerson Barreto Genes (Basel) Article Genomic tools can help in the selection of animals genetically resistant to heat stress, especially the genome-wide association studies (GWAS). The objective of this study was to compare the variance explained by SNPs and direct genomic breeding values (DGVs) at two levels of a temperature and humidity index (THI). Records of milk yield (MY), somatic cell score (SCS), and percentages of casein (CAS), saturated fatty acids (SFA), and unsaturated fatty acids (UFA) in milk from 1157 Holstein cows were used. Traditional breeding values (EBV) were determined in a previous study and used as pseudo-phenotypes. Two levels of THI (heat comfort zone and heat stress zone) were used as environments and were treated as “traits” in a bi-trait model. The GWAS was performed using the genomic best linear unbiased prediction (GBLUP) method. Considering the top 50 SNPs, a total of 36 SNPs were not common between environments, eight of which were located in gene regions related to the evaluated traits. Even for those SNPs that had differences in their explained variances between the two environments, the differences were very small. The animals showed virtually no rank order, with rank correlation values of 0.90, 0.88, 1.00, 0.88, and 0.97 for MY, CAS, SCS, SFA, and UFA, respectively. The small difference between the environments studied can be attributed to the small difference in the pseudo-phenotypes used between the environments, on-farm acclimation, the polygenic nature of the traits, and the THI values studied near the threshold between comfort and heat stress. It is recommended that future studies be conducted with a larger number of animals and at more extreme THI levels. MDPI 2022-12-21 /pmc/articles/PMC9858941/ /pubmed/36672758 http://dx.doi.org/10.3390/genes14010017 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carrara, Eula Regina
Dauria, Brayan Dias
Gervásio, Izally Carvalho
Silveira, Robson Mateus Freitas
Rovadoski, Gregori Alberto
Petrini, Juliana
Salvian, Mayara
Machado, Paulo Fernando
Mourão, Gerson Barreto
Comparison of Marker Effects and Breeding Values at Two Levels at THI for Milk Yield and Quality Traits in Brazilian Holstein Cows
title Comparison of Marker Effects and Breeding Values at Two Levels at THI for Milk Yield and Quality Traits in Brazilian Holstein Cows
title_full Comparison of Marker Effects and Breeding Values at Two Levels at THI for Milk Yield and Quality Traits in Brazilian Holstein Cows
title_fullStr Comparison of Marker Effects and Breeding Values at Two Levels at THI for Milk Yield and Quality Traits in Brazilian Holstein Cows
title_full_unstemmed Comparison of Marker Effects and Breeding Values at Two Levels at THI for Milk Yield and Quality Traits in Brazilian Holstein Cows
title_short Comparison of Marker Effects and Breeding Values at Two Levels at THI for Milk Yield and Quality Traits in Brazilian Holstein Cows
title_sort comparison of marker effects and breeding values at two levels at thi for milk yield and quality traits in brazilian holstein cows
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858941/
https://www.ncbi.nlm.nih.gov/pubmed/36672758
http://dx.doi.org/10.3390/genes14010017
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