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DNA Damage Response and Repair in Boron Neutron Capture Therapy
Boron neutron capture therapy (BNCT) is an approach to the radiotherapy of solid tumors that was first outlined in the 1930s but has attracted considerable attention recently with the advent of a new generation of neutron sources. In BNCT, tumor cells accumulate (10)B atoms that react with epitherma...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859301/ https://www.ncbi.nlm.nih.gov/pubmed/36672868 http://dx.doi.org/10.3390/genes14010127 |
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author | Mechetin, Grigory V. Zharkov, Dmitry O. |
author_facet | Mechetin, Grigory V. Zharkov, Dmitry O. |
author_sort | Mechetin, Grigory V. |
collection | PubMed |
description | Boron neutron capture therapy (BNCT) is an approach to the radiotherapy of solid tumors that was first outlined in the 1930s but has attracted considerable attention recently with the advent of a new generation of neutron sources. In BNCT, tumor cells accumulate (10)B atoms that react with epithermal neutrons, producing energetic α particles and (7)Li atoms that damage the cell’s genome. The damage inflicted by BNCT appears not to be easily repairable and is thus lethal for the cell; however, the molecular events underlying the action of BNCT remain largely unaddressed. In this review, the chemistry of DNA damage during BNCT is outlined, the major mechanisms of DNA break sensing and repair are summarized, and the specifics of the repair of BNCT-induced DNA lesions are discussed. |
format | Online Article Text |
id | pubmed-9859301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98593012023-01-21 DNA Damage Response and Repair in Boron Neutron Capture Therapy Mechetin, Grigory V. Zharkov, Dmitry O. Genes (Basel) Review Boron neutron capture therapy (BNCT) is an approach to the radiotherapy of solid tumors that was first outlined in the 1930s but has attracted considerable attention recently with the advent of a new generation of neutron sources. In BNCT, tumor cells accumulate (10)B atoms that react with epithermal neutrons, producing energetic α particles and (7)Li atoms that damage the cell’s genome. The damage inflicted by BNCT appears not to be easily repairable and is thus lethal for the cell; however, the molecular events underlying the action of BNCT remain largely unaddressed. In this review, the chemistry of DNA damage during BNCT is outlined, the major mechanisms of DNA break sensing and repair are summarized, and the specifics of the repair of BNCT-induced DNA lesions are discussed. MDPI 2023-01-02 /pmc/articles/PMC9859301/ /pubmed/36672868 http://dx.doi.org/10.3390/genes14010127 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mechetin, Grigory V. Zharkov, Dmitry O. DNA Damage Response and Repair in Boron Neutron Capture Therapy |
title | DNA Damage Response and Repair in Boron Neutron Capture Therapy |
title_full | DNA Damage Response and Repair in Boron Neutron Capture Therapy |
title_fullStr | DNA Damage Response and Repair in Boron Neutron Capture Therapy |
title_full_unstemmed | DNA Damage Response and Repair in Boron Neutron Capture Therapy |
title_short | DNA Damage Response and Repair in Boron Neutron Capture Therapy |
title_sort | dna damage response and repair in boron neutron capture therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859301/ https://www.ncbi.nlm.nih.gov/pubmed/36672868 http://dx.doi.org/10.3390/genes14010127 |
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