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Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults
We aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged ≥ 35 from the Chilean National Health Survey 2009–2010. Mortality was determined through linkage with the Chilean Civil Registry and Identificatio...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859421/ https://www.ncbi.nlm.nih.gov/pubmed/36673951 http://dx.doi.org/10.3390/ijerph20021195 |
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author | Diaz-Toro, Felipe Nazar, Gabriela Troncoso, Claudia Concha-Cisternas, Yeny Leiva-Ordoñez, Ana Maria Martinez-Sanguinetti, Maria Adela Parra-Soto, Solange Lasserre-Laso, Nicole Cigarroa, Igor Mardones, Lorena Vásquez-Gómez, Jaime Petermann-Rocha, Fanny Diaz-Martinez, Ximena Celis-Morales, Carlos |
author_facet | Diaz-Toro, Felipe Nazar, Gabriela Troncoso, Claudia Concha-Cisternas, Yeny Leiva-Ordoñez, Ana Maria Martinez-Sanguinetti, Maria Adela Parra-Soto, Solange Lasserre-Laso, Nicole Cigarroa, Igor Mardones, Lorena Vásquez-Gómez, Jaime Petermann-Rocha, Fanny Diaz-Martinez, Ximena Celis-Morales, Carlos |
author_sort | Diaz-Toro, Felipe |
collection | PubMed |
description | We aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged ≥ 35 from the Chilean National Health Survey 2009–2010. Mortality was determined through linkage with the Chilean Civil Registry and Identification. A 36-item frailty index (FI) was used to assess the frailty status. Associations between frailty status and all-cause mortality were assessed using Kaplan–Meier and Cox proportional hazard models adjusted for sociodemographic and lifestyle factors. A non-linear association was investigated using penalized cubic splines fitted in the Cox models. During an 8.9 median follow-up (interquartile range of 8.6–9.0), 308 individuals died (11.5%). Lower survival rates were observed in frail individuals compared to pre-frail and robust people (log-rank < 0.001). Compared with robust individuals, frail people had a higher mortality risk (HR: 2.35 [95% CI: 1.57 to 3.51]). Frail middle-aged individuals had a higher risk of dying independently of major risk factors. |
format | Online Article Text |
id | pubmed-9859421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98594212023-01-21 Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults Diaz-Toro, Felipe Nazar, Gabriela Troncoso, Claudia Concha-Cisternas, Yeny Leiva-Ordoñez, Ana Maria Martinez-Sanguinetti, Maria Adela Parra-Soto, Solange Lasserre-Laso, Nicole Cigarroa, Igor Mardones, Lorena Vásquez-Gómez, Jaime Petermann-Rocha, Fanny Diaz-Martinez, Ximena Celis-Morales, Carlos Int J Environ Res Public Health Article We aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged ≥ 35 from the Chilean National Health Survey 2009–2010. Mortality was determined through linkage with the Chilean Civil Registry and Identification. A 36-item frailty index (FI) was used to assess the frailty status. Associations between frailty status and all-cause mortality were assessed using Kaplan–Meier and Cox proportional hazard models adjusted for sociodemographic and lifestyle factors. A non-linear association was investigated using penalized cubic splines fitted in the Cox models. During an 8.9 median follow-up (interquartile range of 8.6–9.0), 308 individuals died (11.5%). Lower survival rates were observed in frail individuals compared to pre-frail and robust people (log-rank < 0.001). Compared with robust individuals, frail people had a higher mortality risk (HR: 2.35 [95% CI: 1.57 to 3.51]). Frail middle-aged individuals had a higher risk of dying independently of major risk factors. MDPI 2023-01-10 /pmc/articles/PMC9859421/ /pubmed/36673951 http://dx.doi.org/10.3390/ijerph20021195 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Diaz-Toro, Felipe Nazar, Gabriela Troncoso, Claudia Concha-Cisternas, Yeny Leiva-Ordoñez, Ana Maria Martinez-Sanguinetti, Maria Adela Parra-Soto, Solange Lasserre-Laso, Nicole Cigarroa, Igor Mardones, Lorena Vásquez-Gómez, Jaime Petermann-Rocha, Fanny Diaz-Martinez, Ximena Celis-Morales, Carlos Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults |
title | Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults |
title_full | Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults |
title_fullStr | Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults |
title_full_unstemmed | Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults |
title_short | Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults |
title_sort | frailty index as a predictor of mortality in middle-aged and older people: a prospective analysis of chilean adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859421/ https://www.ncbi.nlm.nih.gov/pubmed/36673951 http://dx.doi.org/10.3390/ijerph20021195 |
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