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Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults

We aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged ≥ 35 from the Chilean National Health Survey 2009–2010. Mortality was determined through linkage with the Chilean Civil Registry and Identificatio...

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Autores principales: Diaz-Toro, Felipe, Nazar, Gabriela, Troncoso, Claudia, Concha-Cisternas, Yeny, Leiva-Ordoñez, Ana Maria, Martinez-Sanguinetti, Maria Adela, Parra-Soto, Solange, Lasserre-Laso, Nicole, Cigarroa, Igor, Mardones, Lorena, Vásquez-Gómez, Jaime, Petermann-Rocha, Fanny, Diaz-Martinez, Ximena, Celis-Morales, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859421/
https://www.ncbi.nlm.nih.gov/pubmed/36673951
http://dx.doi.org/10.3390/ijerph20021195
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author Diaz-Toro, Felipe
Nazar, Gabriela
Troncoso, Claudia
Concha-Cisternas, Yeny
Leiva-Ordoñez, Ana Maria
Martinez-Sanguinetti, Maria Adela
Parra-Soto, Solange
Lasserre-Laso, Nicole
Cigarroa, Igor
Mardones, Lorena
Vásquez-Gómez, Jaime
Petermann-Rocha, Fanny
Diaz-Martinez, Ximena
Celis-Morales, Carlos
author_facet Diaz-Toro, Felipe
Nazar, Gabriela
Troncoso, Claudia
Concha-Cisternas, Yeny
Leiva-Ordoñez, Ana Maria
Martinez-Sanguinetti, Maria Adela
Parra-Soto, Solange
Lasserre-Laso, Nicole
Cigarroa, Igor
Mardones, Lorena
Vásquez-Gómez, Jaime
Petermann-Rocha, Fanny
Diaz-Martinez, Ximena
Celis-Morales, Carlos
author_sort Diaz-Toro, Felipe
collection PubMed
description We aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged ≥ 35 from the Chilean National Health Survey 2009–2010. Mortality was determined through linkage with the Chilean Civil Registry and Identification. A 36-item frailty index (FI) was used to assess the frailty status. Associations between frailty status and all-cause mortality were assessed using Kaplan–Meier and Cox proportional hazard models adjusted for sociodemographic and lifestyle factors. A non-linear association was investigated using penalized cubic splines fitted in the Cox models. During an 8.9 median follow-up (interquartile range of 8.6–9.0), 308 individuals died (11.5%). Lower survival rates were observed in frail individuals compared to pre-frail and robust people (log-rank < 0.001). Compared with robust individuals, frail people had a higher mortality risk (HR: 2.35 [95% CI: 1.57 to 3.51]). Frail middle-aged individuals had a higher risk of dying independently of major risk factors.
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spelling pubmed-98594212023-01-21 Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults Diaz-Toro, Felipe Nazar, Gabriela Troncoso, Claudia Concha-Cisternas, Yeny Leiva-Ordoñez, Ana Maria Martinez-Sanguinetti, Maria Adela Parra-Soto, Solange Lasserre-Laso, Nicole Cigarroa, Igor Mardones, Lorena Vásquez-Gómez, Jaime Petermann-Rocha, Fanny Diaz-Martinez, Ximena Celis-Morales, Carlos Int J Environ Res Public Health Article We aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged ≥ 35 from the Chilean National Health Survey 2009–2010. Mortality was determined through linkage with the Chilean Civil Registry and Identification. A 36-item frailty index (FI) was used to assess the frailty status. Associations between frailty status and all-cause mortality were assessed using Kaplan–Meier and Cox proportional hazard models adjusted for sociodemographic and lifestyle factors. A non-linear association was investigated using penalized cubic splines fitted in the Cox models. During an 8.9 median follow-up (interquartile range of 8.6–9.0), 308 individuals died (11.5%). Lower survival rates were observed in frail individuals compared to pre-frail and robust people (log-rank < 0.001). Compared with robust individuals, frail people had a higher mortality risk (HR: 2.35 [95% CI: 1.57 to 3.51]). Frail middle-aged individuals had a higher risk of dying independently of major risk factors. MDPI 2023-01-10 /pmc/articles/PMC9859421/ /pubmed/36673951 http://dx.doi.org/10.3390/ijerph20021195 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Diaz-Toro, Felipe
Nazar, Gabriela
Troncoso, Claudia
Concha-Cisternas, Yeny
Leiva-Ordoñez, Ana Maria
Martinez-Sanguinetti, Maria Adela
Parra-Soto, Solange
Lasserre-Laso, Nicole
Cigarroa, Igor
Mardones, Lorena
Vásquez-Gómez, Jaime
Petermann-Rocha, Fanny
Diaz-Martinez, Ximena
Celis-Morales, Carlos
Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults
title Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults
title_full Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults
title_fullStr Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults
title_full_unstemmed Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults
title_short Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults
title_sort frailty index as a predictor of mortality in middle-aged and older people: a prospective analysis of chilean adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859421/
https://www.ncbi.nlm.nih.gov/pubmed/36673951
http://dx.doi.org/10.3390/ijerph20021195
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