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Improved Trends in the Mortality-to-Incidence Ratios for Liver Cancer in Countries with High Development Index and Health Expenditures

Primary liver cancer is one of the leading causes of death globally. Liver cancer has a unique geographical distribution, as its etiologies include chronic viral infections and aging. We hypothesize that the human development index (HDI), current health expenditure (CHE) per capita, and CHE-to-gross...

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Autores principales: Su, Chang-Cheng, Chen, Brian-Shiian, Chen, Hsin-Hung, Sung, Wen-Wei, Wang, Chi-Chih, Tsai, Ming-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859532/
https://www.ncbi.nlm.nih.gov/pubmed/36673528
http://dx.doi.org/10.3390/healthcare11020159
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author Su, Chang-Cheng
Chen, Brian-Shiian
Chen, Hsin-Hung
Sung, Wen-Wei
Wang, Chi-Chih
Tsai, Ming-Chang
author_facet Su, Chang-Cheng
Chen, Brian-Shiian
Chen, Hsin-Hung
Sung, Wen-Wei
Wang, Chi-Chih
Tsai, Ming-Chang
author_sort Su, Chang-Cheng
collection PubMed
description Primary liver cancer is one of the leading causes of death globally. Liver cancer has a unique geographical distribution, as its etiologies include chronic viral infections and aging. We hypothesize that the human development index (HDI), current health expenditure (CHE) per capita, and CHE-to-gross domestic product ratio (CHE/GDP) influence the incidence, mortality, and mortality-to-incidence ratios (MIRs) of liver cancer worldwide. Data were obtained from the Global Cancer Observatory (GLOBOCAN) database and the World Health Organization. MIRs and the changes in MIR over time (δMIR) were used to evaluate the correlation of expenditures on healthcare and the HDI disparities via Spearman’s rank correlation coefficient. The crude incidence and mortality were significantly associated with HDI, CHE per capita, and CHE/GDP. Specifically, there were significant associations between δMIR and HDI, as well as between δMIR and CHE per capita. However, there were no significant associations between δMIR and CHE/GDP. Evidently, a favorable liver cancer δMIR was not associated with CHE/GDP, although it had a significant association with HDI and CHE per capita. These results are worthy of the attention of public health systems in correlation to improved outcomes in liver cancer.
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spelling pubmed-98595322023-01-21 Improved Trends in the Mortality-to-Incidence Ratios for Liver Cancer in Countries with High Development Index and Health Expenditures Su, Chang-Cheng Chen, Brian-Shiian Chen, Hsin-Hung Sung, Wen-Wei Wang, Chi-Chih Tsai, Ming-Chang Healthcare (Basel) Article Primary liver cancer is one of the leading causes of death globally. Liver cancer has a unique geographical distribution, as its etiologies include chronic viral infections and aging. We hypothesize that the human development index (HDI), current health expenditure (CHE) per capita, and CHE-to-gross domestic product ratio (CHE/GDP) influence the incidence, mortality, and mortality-to-incidence ratios (MIRs) of liver cancer worldwide. Data were obtained from the Global Cancer Observatory (GLOBOCAN) database and the World Health Organization. MIRs and the changes in MIR over time (δMIR) were used to evaluate the correlation of expenditures on healthcare and the HDI disparities via Spearman’s rank correlation coefficient. The crude incidence and mortality were significantly associated with HDI, CHE per capita, and CHE/GDP. Specifically, there were significant associations between δMIR and HDI, as well as between δMIR and CHE per capita. However, there were no significant associations between δMIR and CHE/GDP. Evidently, a favorable liver cancer δMIR was not associated with CHE/GDP, although it had a significant association with HDI and CHE per capita. These results are worthy of the attention of public health systems in correlation to improved outcomes in liver cancer. MDPI 2023-01-04 /pmc/articles/PMC9859532/ /pubmed/36673528 http://dx.doi.org/10.3390/healthcare11020159 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Su, Chang-Cheng
Chen, Brian-Shiian
Chen, Hsin-Hung
Sung, Wen-Wei
Wang, Chi-Chih
Tsai, Ming-Chang
Improved Trends in the Mortality-to-Incidence Ratios for Liver Cancer in Countries with High Development Index and Health Expenditures
title Improved Trends in the Mortality-to-Incidence Ratios for Liver Cancer in Countries with High Development Index and Health Expenditures
title_full Improved Trends in the Mortality-to-Incidence Ratios for Liver Cancer in Countries with High Development Index and Health Expenditures
title_fullStr Improved Trends in the Mortality-to-Incidence Ratios for Liver Cancer in Countries with High Development Index and Health Expenditures
title_full_unstemmed Improved Trends in the Mortality-to-Incidence Ratios for Liver Cancer in Countries with High Development Index and Health Expenditures
title_short Improved Trends in the Mortality-to-Incidence Ratios for Liver Cancer in Countries with High Development Index and Health Expenditures
title_sort improved trends in the mortality-to-incidence ratios for liver cancer in countries with high development index and health expenditures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859532/
https://www.ncbi.nlm.nih.gov/pubmed/36673528
http://dx.doi.org/10.3390/healthcare11020159
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