Cargando…
Optimizing Uptake of Long-Acting Injectable Pre-exposure Prophylaxis for HIV Prevention for Men Who Have Sex with Men
Pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention tool. Long-acting injectable PrEP (LAI-PrEP) offers another opportunity to reduce HIV. However, how at-risk individuals will consider LAI-PrEP over other modes of administration is unclear. We conducted a discrete choice experiment...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859742/ https://www.ncbi.nlm.nih.gov/pubmed/36670210 http://dx.doi.org/10.1007/s10461-023-03986-5 |
_version_ | 1784874427867987968 |
---|---|
author | Dean, Lorraine T. Predmore, Zachary Skinner, Alexandra Napoleon, Siena Chan, Philip A. Raifman, Julia |
author_facet | Dean, Lorraine T. Predmore, Zachary Skinner, Alexandra Napoleon, Siena Chan, Philip A. Raifman, Julia |
author_sort | Dean, Lorraine T. |
collection | PubMed |
description | Pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention tool. Long-acting injectable PrEP (LAI-PrEP) offers another opportunity to reduce HIV. However, how at-risk individuals will consider LAI-PrEP over other modes of administration is unclear. We conducted a discrete choice experiment on preferences for PrEP among a sample of N = 688 gay, bisexual, and other men who have sex with men (GBMSM). We analyzed preferences for mode of administration, side-effects, monetary cost, and time cost using a conditional logit model and predicted preference for PrEP options. LAI-PrEP was preferred, despite mode of administration being the least important PrEP attribute. Side-effects were the most important attribute influencing preferences for PrEP (44% of decision); costs were second-most-important (35% of decision). PrEP with no side-effects was the most important preference, followed by monthly out-of-pocket costs of $0. Practitioners and policymakers looking to increase PrEP uptake should keep costs low, communicate clearly about PrEP side-effects, and allow the use of patient-preferred modes of PrEP administration, including LAI-PrEP. |
format | Online Article Text |
id | pubmed-9859742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-98597422023-01-23 Optimizing Uptake of Long-Acting Injectable Pre-exposure Prophylaxis for HIV Prevention for Men Who Have Sex with Men Dean, Lorraine T. Predmore, Zachary Skinner, Alexandra Napoleon, Siena Chan, Philip A. Raifman, Julia AIDS Behav Original Paper Pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention tool. Long-acting injectable PrEP (LAI-PrEP) offers another opportunity to reduce HIV. However, how at-risk individuals will consider LAI-PrEP over other modes of administration is unclear. We conducted a discrete choice experiment on preferences for PrEP among a sample of N = 688 gay, bisexual, and other men who have sex with men (GBMSM). We analyzed preferences for mode of administration, side-effects, monetary cost, and time cost using a conditional logit model and predicted preference for PrEP options. LAI-PrEP was preferred, despite mode of administration being the least important PrEP attribute. Side-effects were the most important attribute influencing preferences for PrEP (44% of decision); costs were second-most-important (35% of decision). PrEP with no side-effects was the most important preference, followed by monthly out-of-pocket costs of $0. Practitioners and policymakers looking to increase PrEP uptake should keep costs low, communicate clearly about PrEP side-effects, and allow the use of patient-preferred modes of PrEP administration, including LAI-PrEP. Springer US 2023-01-21 2023 /pmc/articles/PMC9859742/ /pubmed/36670210 http://dx.doi.org/10.1007/s10461-023-03986-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Paper Dean, Lorraine T. Predmore, Zachary Skinner, Alexandra Napoleon, Siena Chan, Philip A. Raifman, Julia Optimizing Uptake of Long-Acting Injectable Pre-exposure Prophylaxis for HIV Prevention for Men Who Have Sex with Men |
title | Optimizing Uptake of Long-Acting Injectable Pre-exposure Prophylaxis for HIV Prevention for Men Who Have Sex with Men |
title_full | Optimizing Uptake of Long-Acting Injectable Pre-exposure Prophylaxis for HIV Prevention for Men Who Have Sex with Men |
title_fullStr | Optimizing Uptake of Long-Acting Injectable Pre-exposure Prophylaxis for HIV Prevention for Men Who Have Sex with Men |
title_full_unstemmed | Optimizing Uptake of Long-Acting Injectable Pre-exposure Prophylaxis for HIV Prevention for Men Who Have Sex with Men |
title_short | Optimizing Uptake of Long-Acting Injectable Pre-exposure Prophylaxis for HIV Prevention for Men Who Have Sex with Men |
title_sort | optimizing uptake of long-acting injectable pre-exposure prophylaxis for hiv prevention for men who have sex with men |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859742/ https://www.ncbi.nlm.nih.gov/pubmed/36670210 http://dx.doi.org/10.1007/s10461-023-03986-5 |
work_keys_str_mv | AT deanlorrainet optimizinguptakeoflongactinginjectablepreexposureprophylaxisforhivpreventionformenwhohavesexwithmen AT predmorezachary optimizinguptakeoflongactinginjectablepreexposureprophylaxisforhivpreventionformenwhohavesexwithmen AT skinneralexandra optimizinguptakeoflongactinginjectablepreexposureprophylaxisforhivpreventionformenwhohavesexwithmen AT napoleonsiena optimizinguptakeoflongactinginjectablepreexposureprophylaxisforhivpreventionformenwhohavesexwithmen AT chanphilipa optimizinguptakeoflongactinginjectablepreexposureprophylaxisforhivpreventionformenwhohavesexwithmen AT raifmanjulia optimizinguptakeoflongactinginjectablepreexposureprophylaxisforhivpreventionformenwhohavesexwithmen |