Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling

Osteoarthritis (OA) is the most prevalent joint disorder with increasing worldwide incidence. Mechanistic insights into OA pathophysiology are evolving and there are currently no disease-modifying OA drugs. An increase in protease activity is linked to progressive degradation of the cartilage in OA....

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Detalles Bibliográficos
Autores principales: Chandrabalan, Arundhasa, Firth, Andrew, Litchfield, Robert B., Appleton, C. Thomas, Getgood, Alan, Ramachandran, Rithwik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859807/
https://www.ncbi.nlm.nih.gov/pubmed/36670151
http://dx.doi.org/10.1038/s41598-023-28068-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859807/
https://www.ncbi.nlm.nih.gov/pubmed/36670151
http://dx.doi.org/10.1038/s41598-023-28068-3

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