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Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling

Osteoarthritis (OA) is the most prevalent joint disorder with increasing worldwide incidence. Mechanistic insights into OA pathophysiology are evolving and there are currently no disease-modifying OA drugs. An increase in protease activity is linked to progressive degradation of the cartilage in OA....

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Detalles Bibliográficos
Autores principales:	Chandrabalan, Arundhasa, Firth, Andrew, Litchfield, Robert B., Appleton, C. Thomas, Getgood, Alan, Ramachandran, Rithwik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859807/ https://www.ncbi.nlm.nih.gov/pubmed/36670151 http://dx.doi.org/10.1038/s41598-023-28068-3

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