Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress

The transcriptional response to genotoxic stress involves gene expression arrest, followed by recovery of mRNA synthesis (RRS) after DNA repair. We find that the lack of the EXD2 nuclease impairs RRS and decreases cell survival after UV irradiation, without affecting DNA repair. Overexpression of wi...

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Detalles Bibliográficos
Autores principales: Sandoz, Jérémy, Cigrang, Max, Zachayus, Amélie, Catez, Philippe, Donnio, Lise-Marie, Elly, Clèmence, Nieminuszczy, Jadwiga, Berico, Pietro, Braun, Cathy, Alekseev, Sergey, Egly, Jean-Marc, Niedzwiedz, Wojciech, Giglia-Mari, Giuseppina, Compe, Emmanuel, Coin, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859823/
https://www.ncbi.nlm.nih.gov/pubmed/36670096
http://dx.doi.org/10.1038/s41467-023-35922-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859823/
https://www.ncbi.nlm.nih.gov/pubmed/36670096
http://dx.doi.org/10.1038/s41467-023-35922-5

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