Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options

PURPOSE: Neuromelanin MRI (NM-MRI) is applied as a proxy measurement of dopaminergic functioning of the substantia nigra pars compacta (SN). To increase its clinical applicability, a fast and easily applicable NM-MRI sequence is needed. This study therefore compared accelerated NM-MRI sequences usin...

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Autores principales: van der Pluijm, Marieke, Wallert, Elon D., Coolen, Bram F., Tjong Tjin Joe, Kaithlyn T., de Haan, Lieuwe, Booij, Jan, van de Giessen, Elsmarieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Functional Neuroradiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859863/
https://www.ncbi.nlm.nih.gov/pubmed/36169662
http://dx.doi.org/10.1007/s00234-022-03058-w
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author van der Pluijm, Marieke
Wallert, Elon D.
Coolen, Bram F.
Tjong Tjin Joe, Kaithlyn T.
de Haan, Lieuwe
Booij, Jan
van de Giessen, Elsmarieke
author_facet van der Pluijm, Marieke
Wallert, Elon D.
Coolen, Bram F.
Tjong Tjin Joe, Kaithlyn T.
de Haan, Lieuwe
Booij, Jan
van de Giessen, Elsmarieke
author_sort van der Pluijm, Marieke
collection PubMed
description PURPOSE: Neuromelanin MRI (NM-MRI) is applied as a proxy measurement of dopaminergic functioning of the substantia nigra pars compacta (SN). To increase its clinical applicability, a fast and easily applicable NM-MRI sequence is needed. This study therefore compared accelerated NM-MRI sequences using standard available MRI options with a validated 2D gradient recalled echo NM-MRI sequence with off-resonance magnetization transfer (MT) pulse (2D-MToffRes). METHODS: We used different combinations of compressed sense (CS) acceleration, repetition times (TR), and MT pulse to accelerate the validated 2D-MToffRes. In addition, we compared a recently introduced 3D sequence with the 2D-MToffRes. RESULTS: Our results show that the 2D sequences perform best with good to excellent reliability. Only excellent intraclass correlation coefficients were found for the CS factor 2 sequences. CONCLUSION: We conclude that there are several reliable approaches to accelerate NM-MRI, in particular by using CS.
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spelling pubmed-98598632023-01-22 Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options van der Pluijm, Marieke Wallert, Elon D. Coolen, Bram F. Tjong Tjin Joe, Kaithlyn T. de Haan, Lieuwe Booij, Jan van de Giessen, Elsmarieke Neuroradiology Functional Neuroradiology PURPOSE: Neuromelanin MRI (NM-MRI) is applied as a proxy measurement of dopaminergic functioning of the substantia nigra pars compacta (SN). To increase its clinical applicability, a fast and easily applicable NM-MRI sequence is needed. This study therefore compared accelerated NM-MRI sequences using standard available MRI options with a validated 2D gradient recalled echo NM-MRI sequence with off-resonance magnetization transfer (MT) pulse (2D-MToffRes). METHODS: We used different combinations of compressed sense (CS) acceleration, repetition times (TR), and MT pulse to accelerate the validated 2D-MToffRes. In addition, we compared a recently introduced 3D sequence with the 2D-MToffRes. RESULTS: Our results show that the 2D sequences perform best with good to excellent reliability. Only excellent intraclass correlation coefficients were found for the CS factor 2 sequences. CONCLUSION: We conclude that there are several reliable approaches to accelerate NM-MRI, in particular by using CS. Springer Berlin Heidelberg 2022-09-28 2023 /pmc/articles/PMC9859863/ /pubmed/36169662 http://dx.doi.org/10.1007/s00234-022-03058-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Functional Neuroradiology
van der Pluijm, Marieke
Wallert, Elon D.
Coolen, Bram F.
Tjong Tjin Joe, Kaithlyn T.
de Haan, Lieuwe
Booij, Jan
van de Giessen, Elsmarieke
Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options
title Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options
title_full Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options
title_fullStr Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options
title_full_unstemmed Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options
title_short Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options
title_sort acceleration of neuromelanin-sensitive mri sequences in the substantia nigra using standard mri options
topic Functional Neuroradiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859863/
https://www.ncbi.nlm.nih.gov/pubmed/36169662
http://dx.doi.org/10.1007/s00234-022-03058-w
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