Stochastic epigenetic mutations as possible explanation for phenotypical discordance among twins with congenital hypothyroidism

PURPOSE: The elevated frequency of discordance for congenital hypothyroidism (CH) phenotype between monozygotic twins suggests the involvement of non-mendelian mechanisms. The aim of the study was to investigate the role of epigenetics in CH pathogenesis. METHODS: A genome-wide DNA methylation analy...

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Detalles Bibliográficos
Autores principales: Gentilini, D., Muzza, M., de Filippis, T., Vigone, M. C., Weber, G., Calzari, L., Cassio, A., Di Frenna, M., Bartolucci, M., Grassi, E. S., Carbone, E., Olivieri, A., Persani, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859866/
https://www.ncbi.nlm.nih.gov/pubmed/36071330
http://dx.doi.org/10.1007/s40618-022-01915-2

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