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Circulating tumor cells correlating with Ki-67 predicts the prognosis of bladder cancer patients

PURPOSE: To investigate the value of circulating tumor cells (CTCs) and Ki-67 in predicting the prognosis of bladder cancer. Here, we tested CTC counts and Ki-67 levels to assess patient prognosis. METHODS: 84 patients with bladder cancer who underwent surgery were included in this study. Peripheral...

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Autores principales: Liu, Jie, Ma, Cailing, Li, Xiaohang, Li, Anan, Wang, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859911/
https://www.ncbi.nlm.nih.gov/pubmed/36334226
http://dx.doi.org/10.1007/s11255-022-03406-y
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author Liu, Jie
Ma, Cailing
Li, Xiaohang
Li, Anan
Wang, Zhiyong
author_facet Liu, Jie
Ma, Cailing
Li, Xiaohang
Li, Anan
Wang, Zhiyong
author_sort Liu, Jie
collection PubMed
description PURPOSE: To investigate the value of circulating tumor cells (CTCs) and Ki-67 in predicting the prognosis of bladder cancer. Here, we tested CTC counts and Ki-67 levels to assess patient prognosis. METHODS: 84 patients with bladder cancer who underwent surgery were included in this study. Peripheral blood CTCs were detected by SE-iFISH technology before and after surgery, and Ki-67 levels were analyzed by immunohistochemistry. The association between CTCs and Ki-67 and the combination of the two was analyzed to predict the prognosis of patients. RESULTS: 76 out of 84 patients (90.5%) were positive. ROC curve analysis showed that preoperative and postoperative CTC counts = 4 and 2 were the best thresholds for predicting patient recurrence or death. In multivariate analysis, high postoperative CTC count (≥ 2) (P < 0.001) and Ki-67 high expression (≥ 15%) (P < 0.001) were independent poor prognostic factors for PFS in bladder cancer patients. In addition, the study found that Ki-67 levels were positively correlated with high postoperative CTC counts, Bladder cancer patients with Ki-67 high expression and high postoperative CTC counts were associated with extremely poor progression-free survival. CONCLUSION: Ki-67 high expression is associated with high postoperative CTC counts, both of which predict poor prognosis in bladder cancer patients.
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spelling pubmed-98599112023-01-22 Circulating tumor cells correlating with Ki-67 predicts the prognosis of bladder cancer patients Liu, Jie Ma, Cailing Li, Xiaohang Li, Anan Wang, Zhiyong Int Urol Nephrol Urology - Original Paper PURPOSE: To investigate the value of circulating tumor cells (CTCs) and Ki-67 in predicting the prognosis of bladder cancer. Here, we tested CTC counts and Ki-67 levels to assess patient prognosis. METHODS: 84 patients with bladder cancer who underwent surgery were included in this study. Peripheral blood CTCs were detected by SE-iFISH technology before and after surgery, and Ki-67 levels were analyzed by immunohistochemistry. The association between CTCs and Ki-67 and the combination of the two was analyzed to predict the prognosis of patients. RESULTS: 76 out of 84 patients (90.5%) were positive. ROC curve analysis showed that preoperative and postoperative CTC counts = 4 and 2 were the best thresholds for predicting patient recurrence or death. In multivariate analysis, high postoperative CTC count (≥ 2) (P < 0.001) and Ki-67 high expression (≥ 15%) (P < 0.001) were independent poor prognostic factors for PFS in bladder cancer patients. In addition, the study found that Ki-67 levels were positively correlated with high postoperative CTC counts, Bladder cancer patients with Ki-67 high expression and high postoperative CTC counts were associated with extremely poor progression-free survival. CONCLUSION: Ki-67 high expression is associated with high postoperative CTC counts, both of which predict poor prognosis in bladder cancer patients. Springer Netherlands 2022-11-05 2023 /pmc/articles/PMC9859911/ /pubmed/36334226 http://dx.doi.org/10.1007/s11255-022-03406-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Urology - Original Paper
Liu, Jie
Ma, Cailing
Li, Xiaohang
Li, Anan
Wang, Zhiyong
Circulating tumor cells correlating with Ki-67 predicts the prognosis of bladder cancer patients
title Circulating tumor cells correlating with Ki-67 predicts the prognosis of bladder cancer patients
title_full Circulating tumor cells correlating with Ki-67 predicts the prognosis of bladder cancer patients
title_fullStr Circulating tumor cells correlating with Ki-67 predicts the prognosis of bladder cancer patients
title_full_unstemmed Circulating tumor cells correlating with Ki-67 predicts the prognosis of bladder cancer patients
title_short Circulating tumor cells correlating with Ki-67 predicts the prognosis of bladder cancer patients
title_sort circulating tumor cells correlating with ki-67 predicts the prognosis of bladder cancer patients
topic Urology - Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859911/
https://www.ncbi.nlm.nih.gov/pubmed/36334226
http://dx.doi.org/10.1007/s11255-022-03406-y
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