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Impact of host age on viral and bacterial communities in a waterbird population

Wildlife harbour pathogens that can harm human or livestock health and are the source of most emerging infectious diseases. It is rarely considered how changes in wildlife population age-structures or how age-stratified behaviours might alter the level of pathogen detection within a species, or risk...

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Autores principales: Hill, Sarah C., François, Sarah, Thézé, Julien, Smith, Adrian L., Simmonds, Peter, Perrins, Christopher M., van der Hoek, Lia, Pybus, Oliver G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860062/
https://www.ncbi.nlm.nih.gov/pubmed/36319706
http://dx.doi.org/10.1038/s41396-022-01334-4
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author Hill, Sarah C.
François, Sarah
Thézé, Julien
Smith, Adrian L.
Simmonds, Peter
Perrins, Christopher M.
van der Hoek, Lia
Pybus, Oliver G.
author_facet Hill, Sarah C.
François, Sarah
Thézé, Julien
Smith, Adrian L.
Simmonds, Peter
Perrins, Christopher M.
van der Hoek, Lia
Pybus, Oliver G.
author_sort Hill, Sarah C.
collection PubMed
description Wildlife harbour pathogens that can harm human or livestock health and are the source of most emerging infectious diseases. It is rarely considered how changes in wildlife population age-structures or how age-stratified behaviours might alter the level of pathogen detection within a species, or risk of spillover to other species. Micro-organisms that occur in healthy animals can be an important model for understanding and predicting the dynamics of pathogens of greater health concern, which are hard to study in wild populations due to their relative rarity. We therefore used a metagenomic approach to jointly characterise viral and prokaryotic carriage in faeces collected from a healthy wild bird population (Cygnus olor; mute swan) that has been subject to long-term study. Using 223 samples from known individuals allowed us to compare differences in prokaryotic and eukaryotic viral carriage between adults and juveniles at an unprecedented level of detail. We discovered and characterised 77 novel virus species, of which 21% belong putatively to bird-infecting families, and described the core prokaryotic microbiome of C. olor. Whilst no difference in microbiota diversity was observed between juveniles and adult individuals, 50% (4/8) of bird-infecting virus families (picornaviruses, astroviruses, adenoviruses and bornaviruses) and 3.4% (9/267) of prokaryotic families (including Helicobacteraceae, Spirochaetaceae and Flavobacteriaceae families) were differentially abundant and/or prevalent between juveniles and adults. This indicates that perturbations that affect population age-structures of wildlife could alter circulation dynamics and spillover risk of microbes, potentially including pathogens.
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spelling pubmed-98600622023-01-22 Impact of host age on viral and bacterial communities in a waterbird population Hill, Sarah C. François, Sarah Thézé, Julien Smith, Adrian L. Simmonds, Peter Perrins, Christopher M. van der Hoek, Lia Pybus, Oliver G. ISME J Article Wildlife harbour pathogens that can harm human or livestock health and are the source of most emerging infectious diseases. It is rarely considered how changes in wildlife population age-structures or how age-stratified behaviours might alter the level of pathogen detection within a species, or risk of spillover to other species. Micro-organisms that occur in healthy animals can be an important model for understanding and predicting the dynamics of pathogens of greater health concern, which are hard to study in wild populations due to their relative rarity. We therefore used a metagenomic approach to jointly characterise viral and prokaryotic carriage in faeces collected from a healthy wild bird population (Cygnus olor; mute swan) that has been subject to long-term study. Using 223 samples from known individuals allowed us to compare differences in prokaryotic and eukaryotic viral carriage between adults and juveniles at an unprecedented level of detail. We discovered and characterised 77 novel virus species, of which 21% belong putatively to bird-infecting families, and described the core prokaryotic microbiome of C. olor. Whilst no difference in microbiota diversity was observed between juveniles and adult individuals, 50% (4/8) of bird-infecting virus families (picornaviruses, astroviruses, adenoviruses and bornaviruses) and 3.4% (9/267) of prokaryotic families (including Helicobacteraceae, Spirochaetaceae and Flavobacteriaceae families) were differentially abundant and/or prevalent between juveniles and adults. This indicates that perturbations that affect population age-structures of wildlife could alter circulation dynamics and spillover risk of microbes, potentially including pathogens. Nature Publishing Group UK 2022-11-01 2023-02 /pmc/articles/PMC9860062/ /pubmed/36319706 http://dx.doi.org/10.1038/s41396-022-01334-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hill, Sarah C.
François, Sarah
Thézé, Julien
Smith, Adrian L.
Simmonds, Peter
Perrins, Christopher M.
van der Hoek, Lia
Pybus, Oliver G.
Impact of host age on viral and bacterial communities in a waterbird population
title Impact of host age on viral and bacterial communities in a waterbird population
title_full Impact of host age on viral and bacterial communities in a waterbird population
title_fullStr Impact of host age on viral and bacterial communities in a waterbird population
title_full_unstemmed Impact of host age on viral and bacterial communities in a waterbird population
title_short Impact of host age on viral and bacterial communities in a waterbird population
title_sort impact of host age on viral and bacterial communities in a waterbird population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860062/
https://www.ncbi.nlm.nih.gov/pubmed/36319706
http://dx.doi.org/10.1038/s41396-022-01334-4
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