Gene regulatory network reconfiguration in direct lineage reprogramming

In direct lineage conversion, transcription factor (TF) overexpression reconfigures gene regulatory networks (GRNs) to reprogram cell identity. We previously developed CellOracle, a computational method to infer GRNs from single-cell transcriptome and epigenome data. Using inferred GRNs, CellOracle...

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Detalles Bibliográficos
Autores principales: Kamimoto, Kenji, Adil, Mohd Tayyab, Jindal, Kunal, Hoffmann, Christy M., Kong, Wenjun, Yang, Xue, Morris, Samantha A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860067/
https://www.ncbi.nlm.nih.gov/pubmed/36584685
http://dx.doi.org/10.1016/j.stemcr.2022.11.010

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