Dysregulated Polycomb Repressive Complex 2 contributes to chronic obstructive pulmonary disease by rewiring stem cell fate

Aberrant lung cell differentiation is a hallmark of many lung diseases including chronic obstructive pulmonary disease (COPD). The EZH2-containing Polycomb Repressive Complex 2 (PRC2) regulates embryonic lung stem cell fate, but its role in adult lung is obscure. Histological analysis of patient tis...

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Detalles Bibliográficos
Autores principales: Byrd, Aria L., Qu, Xufeng, Lukyanchuk, Alexsandr, Liu, Jinpeng, Chen, Fan, Naughton, Kassandra J., DuCote, Tanner J., Song, Xiulong, Bowman, Hannah C., Zhao, Yanming, Edgin, Abigail R., Wang, Chi, Liu, Jinze, Brainson, Christine Fillmore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860081/
https://www.ncbi.nlm.nih.gov/pubmed/36525966
http://dx.doi.org/10.1016/j.stemcr.2022.11.009

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