Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity

Histone deacetylase 6 (HDAC6) is an attractive drug development target because of its role in the immune response, neuropathy, and cancer. Knockout mice develop normally and have no apparent phenotype, suggesting that selective inhibitors should have an excellent therapeutic window. Unfortunately, c...

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Detalles Bibliográficos
Autores principales: Cellupica, Edoardo, Caprini, Gianluca, Cordella, Paola, Cukier, Cyprian, Fossati, Gianluca, Marchini, Mattia, Rocchio, Ilaria, Sandrone, Giovanni, Vanoni, Maria Antonietta, Vergani, Barbara, Źrubek, Karol, Stevenazzi, Andrea, Steinkühler, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
JBC Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860109/
https://www.ncbi.nlm.nih.gov/pubmed/36528061
http://dx.doi.org/10.1016/j.jbc.2022.102800

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