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Retention of ERK in the cytoplasm mediates the pluripotency of embryonic stem cells

The dynamic subcellular localization of ERK1/2 plays an important role in regulating cell fate. Differentiation of mouse embryonic stem cells (mESCs) involves inductive stimulation of ERK1/2, and therefore, inhibitors of the ERK cascade are used to maintain pluripotency. Interestingly, we found that...

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Detalles Bibliográficos
Autores principales:	Hacohen Lev-Ran, Avital, Seger, Rony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860118/ https://www.ncbi.nlm.nih.gov/pubmed/36563690 http://dx.doi.org/10.1016/j.stemcr.2022.11.017

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