Production of large, defined genome modifications in rats by targeting rat embryonic stem cells

Rats were more frequently used than mice to model human disease before mouse embryonic stem cells (mESCs) revolutionized genetic engineering in mice. Rat ESCs (rESCs) were first reported over 10 years ago, yet they are not as frequently used as mESCs. CRISPR-based gene editing in zygotes is widely u...

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Detalles Bibliográficos
Autores principales: Lee, Jeffrey, Wang, Jingjing, Ally, Roxanne, Trzaska, Sean, Hickey, Joseph, Mujica, Alejo, Miloscio, Lawrence, Mastaitis, Jason, Morse, Brian, Smith, Janell, Atanasio, Amanda, Chiao, Eric, Chen, Henry, Latuszek, Adrianna, Hu, Ying, Valenzuela, David, Romano, Carmelo, Zambrowicz, Brian, Auerbach, Wojtek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860120/
https://www.ncbi.nlm.nih.gov/pubmed/36525967
http://dx.doi.org/10.1016/j.stemcr.2022.11.012

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