Charge neutralization of the active site glutamates does not limit substrate binding and transport by small multidrug resistance transporter EmrE

EmrE, a small multidrug resistance transporter from Escherichia coli, confers broad-spectrum resistance to polyaromatic cations and quaternary ammonium compounds. Previous transport assays demonstrate that EmrE transports a +1 and a +2 substrate with the same stoichiometry of two protons:one cationi...

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Detalles Bibliográficos
Autores principales: Spreacker, Peyton J., Brousseau, Merissa, Hisao, Grant S., Soltani, Mohammad, Davis, James H., Henzler-Wildman, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860125/
https://www.ncbi.nlm.nih.gov/pubmed/36529287
http://dx.doi.org/10.1016/j.jbc.2022.102805

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