Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

In the brain, the complement system plays a crucial role in the immune response and in synaptic elimination during normal development and disease. Here, we sought to identify pathways that modulate the production of complement component 4 (C4), recently associated with an increased risk of schizophr...

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Detalles Bibliográficos
Autores principales: Rapino, Francesca, Natoli, Ted, Limone, Francesco, O’Connor, Erin, Blank, Jack, Tegtmeyer, Matthew, Chen, William, Norabuena, Erika, Narula, Juhi, Hazelbaker, Dane, Angelini, Gabriella, Barrett, Lindy, O’Neil, Alison, Beattie, Ursula K., Thanos, Jessica M., de Rivera, Heather, Sheridan, Steven D., Perlis, Roy H., McCarroll, Steven A., Stevens, Beth, Subramanian, Aravind, Nehme, Ralda, Rubin, Lee L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860128/
https://www.ncbi.nlm.nih.gov/pubmed/36563689
http://dx.doi.org/10.1016/j.stemcr.2022.11.018

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