Enhancer architecture and chromatin accessibility constrain phenotypic space during Drosophila development

Developmental enhancers bind transcription factors and dictate patterns of gene expression during development. Their molecular evolution can underlie phenotypical evolution, but the contributions of the evolutionary pathways involved remain little understood. Here, using mutation libraries in Drosop...

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Detalles Bibliográficos
Autores principales: Galupa, Rafael, Alvarez-Canales, Gilberto, Borst, Noa Ottilie, Fuqua, Timothy, Gandara, Lautaro, Misunou, Natalia, Richter, Kerstin, Alves, Mariana R.P., Karumbi, Esther, Perkins, Melinda Liu, Kocijan, Tin, Rushlow, Christine A., Crocker, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860173/
https://www.ncbi.nlm.nih.gov/pubmed/36626871
http://dx.doi.org/10.1016/j.devcel.2022.12.003

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