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A diminished hydrophobic effect inside the GroEL/ES cavity contributes to protein substrate destabilization
Confining compartments are ubiquitous in biology, but there have been few experimental studies on the thermodynamics of protein folding in such environments. Recently, we reported that the stability of a model protein substrate in the GroEL/ES chaperonin cage is reduced dramatically by more than 5 k...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860310/ https://www.ncbi.nlm.nih.gov/pubmed/36409898 http://dx.doi.org/10.1073/pnas.2213170119 |