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The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids
Fatty acids are vital for the survival of eukaryotes, but when present in excess can have deleterious consequences. The AMP-activated protein kinase (AMPK) is an important regulator of multiple branches of metabolism. Studies in purified enzyme preparations and cultured cells have shown that AMPK is...
Autores principales: | Desjardins, Eric M., Smith, Brennan K., Day, Emily A., Ducommun, Serge, Sanders, Matthew J., Nederveen, Joshua P., Ford, Rebecca J., Pinkosky, Stephen L., Townsend, Logan K., Gutgesell, Robert M., Lu, Rachel, Sakamoto, Kei, Steinberg, Gregory R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860314/ https://www.ncbi.nlm.nih.gov/pubmed/36409897 http://dx.doi.org/10.1073/pnas.2119824119 |
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