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A study on alterations in functional activity in migraineurs during the interictal period

Migraine is a recurrent disease in which the cumulative effect of repeated pain attacks over a long period of time causes changes in brain function. Although there are some studies focusing on the interictal period of migraine, the reproducibility of these results is poor. Therefore, we intend to us...

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Autores principales: Wu, Lanxiang, Wang, Xuan, Liu, Qian, Chai, Lijun, Tian, Sheng, Wu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860458/
https://www.ncbi.nlm.nih.gov/pubmed/36691529
http://dx.doi.org/10.1016/j.heliyon.2022.e12372
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author Wu, Lanxiang
Wang, Xuan
Liu, Qian
Chai, Lijun
Tian, Sheng
Wu, Wei
author_facet Wu, Lanxiang
Wang, Xuan
Liu, Qian
Chai, Lijun
Tian, Sheng
Wu, Wei
author_sort Wu, Lanxiang
collection PubMed
description Migraine is a recurrent disease in which the cumulative effect of repeated pain attacks over a long period of time causes changes in brain function. Although there are some studies focusing on the interictal period of migraine, the reproducibility of these results is poor. Therefore, we intend to use a data-driven functional connectivity (FC) approach to probe the alterations in cerebral functional activity during the interictal period, as well as underlying no-task mechanisms of inducing headache attack in migraine patients. In the current research, 24 episodic migraine patients and 23 healthy controls (HCs) were recruited. By analyzing the magnitude of regional homogeneity (ReHo) and low-frequency fractional fluctuation (fALFF), We identified alterations in spontaneous brain activity in migraineurs, including the bilateral middle frontal gyrus, left postcentral, and right lingual gyrus. Thereafter such abnormalities were selected as seeds (ROIs) for FC analysis to further explore the underlying changes between ROIs and the whole brain areas. Compared with HCs, FC between the right middle frontal gyrus with the left precuneus cortex, and bilateral thalamus were enhanced in migraineurs. In addition, increased FC has been showed between the left postcentral gyrus with the bilateral thalamus. Furthermore, negative correlation existed between fALFF values of the left middle frontal gyrus and the pain intensity of migraine attacks (r = −0.4578, p = 0.0245). In summary, abnormal FC between the bilateral thalamus and right middle frontal gyrus, or the left retrocentral gyrus may occur between attacks in migraineurs, which may be the basis for sensory integration and pain regulation dysfunction. Thus, this could become a promising biomarker for the early diagnosis and evaluation of migraine in the interictal period, and provide a novel view for further investigation of the pathogenesis and etiology of recurrent migraine.
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spelling pubmed-98604582023-01-22 A study on alterations in functional activity in migraineurs during the interictal period Wu, Lanxiang Wang, Xuan Liu, Qian Chai, Lijun Tian, Sheng Wu, Wei Heliyon Research Article Migraine is a recurrent disease in which the cumulative effect of repeated pain attacks over a long period of time causes changes in brain function. Although there are some studies focusing on the interictal period of migraine, the reproducibility of these results is poor. Therefore, we intend to use a data-driven functional connectivity (FC) approach to probe the alterations in cerebral functional activity during the interictal period, as well as underlying no-task mechanisms of inducing headache attack in migraine patients. In the current research, 24 episodic migraine patients and 23 healthy controls (HCs) were recruited. By analyzing the magnitude of regional homogeneity (ReHo) and low-frequency fractional fluctuation (fALFF), We identified alterations in spontaneous brain activity in migraineurs, including the bilateral middle frontal gyrus, left postcentral, and right lingual gyrus. Thereafter such abnormalities were selected as seeds (ROIs) for FC analysis to further explore the underlying changes between ROIs and the whole brain areas. Compared with HCs, FC between the right middle frontal gyrus with the left precuneus cortex, and bilateral thalamus were enhanced in migraineurs. In addition, increased FC has been showed between the left postcentral gyrus with the bilateral thalamus. Furthermore, negative correlation existed between fALFF values of the left middle frontal gyrus and the pain intensity of migraine attacks (r = −0.4578, p = 0.0245). In summary, abnormal FC between the bilateral thalamus and right middle frontal gyrus, or the left retrocentral gyrus may occur between attacks in migraineurs, which may be the basis for sensory integration and pain regulation dysfunction. Thus, this could become a promising biomarker for the early diagnosis and evaluation of migraine in the interictal period, and provide a novel view for further investigation of the pathogenesis and etiology of recurrent migraine. Elsevier 2022-12-16 /pmc/articles/PMC9860458/ /pubmed/36691529 http://dx.doi.org/10.1016/j.heliyon.2022.e12372 Text en © 2022 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Wu, Lanxiang
Wang, Xuan
Liu, Qian
Chai, Lijun
Tian, Sheng
Wu, Wei
A study on alterations in functional activity in migraineurs during the interictal period
title A study on alterations in functional activity in migraineurs during the interictal period
title_full A study on alterations in functional activity in migraineurs during the interictal period
title_fullStr A study on alterations in functional activity in migraineurs during the interictal period
title_full_unstemmed A study on alterations in functional activity in migraineurs during the interictal period
title_short A study on alterations in functional activity in migraineurs during the interictal period
title_sort study on alterations in functional activity in migraineurs during the interictal period
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860458/
https://www.ncbi.nlm.nih.gov/pubmed/36691529
http://dx.doi.org/10.1016/j.heliyon.2022.e12372
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