Nucleotide addition and cleavage by RNA polymerase II: Coordination of two catalytic reactions using a single active site

RNA polymerase II (Pol II) incorporates complementary ribonucleotides into the growing RNA chain one at a time via the nucleotide addition cycle. The nucleotide addition cycle, however, is prone to misincorporation of noncomplementary nucleotides. Thus, to ensure transcriptional fidelity, Pol II bac...

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Detalles Bibliográficos
Autores principales: Unarta, Ilona Christy, Goonetilleke, Eshani C., Wang, Dong, Huang, Xuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
JBC Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860460/
https://www.ncbi.nlm.nih.gov/pubmed/36581202
http://dx.doi.org/10.1016/j.jbc.2022.102844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860460/
https://www.ncbi.nlm.nih.gov/pubmed/36581202
http://dx.doi.org/10.1016/j.jbc.2022.102844

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