Drug-independent NADPH-consuming micelles collaborate with ROS-generator for cascade ferroptosis amplification by impairing redox homeostasis

Ferroptosis as promising antitumor therapy strategy could be comprised by intracellular antioxidants, especially GSH and thioredoxin (Trx). They are both cofactors of Gpx4, the enzyme catalyzing the production of lipid peroxides to relieve oxidative stress, which drives the acquired ferroptosis resi...

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Detalles Bibliográficos
Autores principales: Yu, Fangying, Shang, Xuwei, Wang, Zixu, Zhu, Yun, Chen, Simin, Yuan, Hong, Hu, Fuqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860483/
https://www.ncbi.nlm.nih.gov/pubmed/36691607
http://dx.doi.org/10.1016/j.mtbio.2022.100532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860483/
https://www.ncbi.nlm.nih.gov/pubmed/36691607
http://dx.doi.org/10.1016/j.mtbio.2022.100532

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