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Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials

Neurodegenerative diseases are caused by the gradual loss of neurons’ function. These neurological illnesses remain incurable, and current medicines only alleviate the symptoms. Given the social and economic burden caused by the rising frequency of neurodegenerative diseases, there is an urgent need...

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Autores principales: Andrade, Stéphanie, Nunes, Débora, Dabur, Meghna, Ramalho, Maria J., Pereira, Maria C., Loureiro, Joana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860553/
https://www.ncbi.nlm.nih.gov/pubmed/36678841
http://dx.doi.org/10.3390/pharmaceutics15010212
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author Andrade, Stéphanie
Nunes, Débora
Dabur, Meghna
Ramalho, Maria J.
Pereira, Maria C.
Loureiro, Joana A.
author_facet Andrade, Stéphanie
Nunes, Débora
Dabur, Meghna
Ramalho, Maria J.
Pereira, Maria C.
Loureiro, Joana A.
author_sort Andrade, Stéphanie
collection PubMed
description Neurodegenerative diseases are caused by the gradual loss of neurons’ function. These neurological illnesses remain incurable, and current medicines only alleviate the symptoms. Given the social and economic burden caused by the rising frequency of neurodegenerative diseases, there is an urgent need for the development of appropriate therapeutics. Natural compounds are gaining popularity as alternatives to synthetic drugs due to their neuroprotective properties and higher biocompatibility. While natural compounds’ therapeutic effects for neurodegenerative disease treatment have been investigated in numerous in vitro and in vivo studies, only few have moved to clinical trials. This article provides the first systematic review of the clinical trials evaluating natural compounds’ safety and efficacy for the treatment of the five most prevalent neurodegenerative disorders: Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease.
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spelling pubmed-98605532023-01-22 Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials Andrade, Stéphanie Nunes, Débora Dabur, Meghna Ramalho, Maria J. Pereira, Maria C. Loureiro, Joana A. Pharmaceutics Review Neurodegenerative diseases are caused by the gradual loss of neurons’ function. These neurological illnesses remain incurable, and current medicines only alleviate the symptoms. Given the social and economic burden caused by the rising frequency of neurodegenerative diseases, there is an urgent need for the development of appropriate therapeutics. Natural compounds are gaining popularity as alternatives to synthetic drugs due to their neuroprotective properties and higher biocompatibility. While natural compounds’ therapeutic effects for neurodegenerative disease treatment have been investigated in numerous in vitro and in vivo studies, only few have moved to clinical trials. This article provides the first systematic review of the clinical trials evaluating natural compounds’ safety and efficacy for the treatment of the five most prevalent neurodegenerative disorders: Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease. MDPI 2023-01-07 /pmc/articles/PMC9860553/ /pubmed/36678841 http://dx.doi.org/10.3390/pharmaceutics15010212 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Andrade, Stéphanie
Nunes, Débora
Dabur, Meghna
Ramalho, Maria J.
Pereira, Maria C.
Loureiro, Joana A.
Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials
title Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials
title_full Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials
title_fullStr Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials
title_full_unstemmed Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials
title_short Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials
title_sort therapeutic potential of natural compounds in neurodegenerative diseases: insights from clinical trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860553/
https://www.ncbi.nlm.nih.gov/pubmed/36678841
http://dx.doi.org/10.3390/pharmaceutics15010212
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