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Adrenal Gland Primary Neuroblastoma in an Adult Patient: A Case Report and Literature Review

Neuroblastoma (NB) is an undifferentiated malignant tumor of the sympathetic ganglia, occurring in children under 5 years of age. However, it is a rare histology in adult patients, occurring once per every 10 million patients per year. We present the case of a 68-year-old male patient presented to o...

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Autores principales: Telecan, Teodora, Andras, Iulia, Bungardean, Maria Raluca, Muntean, Diana, Militaru, Claudia, Perciuleac, Ion, Maga, Andrei, Crisan, Nicolae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860607/
https://www.ncbi.nlm.nih.gov/pubmed/36676657
http://dx.doi.org/10.3390/medicina59010033
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author Telecan, Teodora
Andras, Iulia
Bungardean, Maria Raluca
Muntean, Diana
Militaru, Claudia
Perciuleac, Ion
Maga, Andrei
Crisan, Nicolae
author_facet Telecan, Teodora
Andras, Iulia
Bungardean, Maria Raluca
Muntean, Diana
Militaru, Claudia
Perciuleac, Ion
Maga, Andrei
Crisan, Nicolae
author_sort Telecan, Teodora
collection PubMed
description Neuroblastoma (NB) is an undifferentiated malignant tumor of the sympathetic ganglia, occurring in children under 5 years of age. However, it is a rare histology in adult patients, occurring once per every 10 million patients per year. We present the case of a 68-year-old male patient presented to our department for right lumbar pain, asthenia, loss of weight and altered general status. The contrast-enhanced abdominal computer tomography revealed bilateral adrenal tumoral masses of 149 mm and 82 mm on the right and left sides, respectively, with invasion of the surrounding organs. The patient underwent right 3D laparoscopic adrenalectomy and right radical nephrectomy. The pathological result concluded that the excised tumor was a neuroblastoma of the adrenal gland. The patient followed adjuvant oncological treatment; however, due to disease progression, he passed away 22 months after the surgery. To our knowledge, less than 100 cases of adrenal NB in adult patients have been published, the eldest case being diagnosed at 75 years of age; meanwhile, the largest reported tumor measured 200 mm, and was excised through open surgery. Minimally invasive techniques have been limited so far to smaller, organ-confined diseases, thus making the present case the largest adrenal NB removed entirely laparoscopically. Neuroblastoma in the adult population is a rare finding, with worse prognosis compared to pediatric patients. The available literature does not provide enough data for standardized, multimodal management, as the patients are treated following adapted pediatric protocols, thus reinforcing the need for international, multidisciplinary boards for rare tumors.
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spelling pubmed-98606072023-01-22 Adrenal Gland Primary Neuroblastoma in an Adult Patient: A Case Report and Literature Review Telecan, Teodora Andras, Iulia Bungardean, Maria Raluca Muntean, Diana Militaru, Claudia Perciuleac, Ion Maga, Andrei Crisan, Nicolae Medicina (Kaunas) Case Report Neuroblastoma (NB) is an undifferentiated malignant tumor of the sympathetic ganglia, occurring in children under 5 years of age. However, it is a rare histology in adult patients, occurring once per every 10 million patients per year. We present the case of a 68-year-old male patient presented to our department for right lumbar pain, asthenia, loss of weight and altered general status. The contrast-enhanced abdominal computer tomography revealed bilateral adrenal tumoral masses of 149 mm and 82 mm on the right and left sides, respectively, with invasion of the surrounding organs. The patient underwent right 3D laparoscopic adrenalectomy and right radical nephrectomy. The pathological result concluded that the excised tumor was a neuroblastoma of the adrenal gland. The patient followed adjuvant oncological treatment; however, due to disease progression, he passed away 22 months after the surgery. To our knowledge, less than 100 cases of adrenal NB in adult patients have been published, the eldest case being diagnosed at 75 years of age; meanwhile, the largest reported tumor measured 200 mm, and was excised through open surgery. Minimally invasive techniques have been limited so far to smaller, organ-confined diseases, thus making the present case the largest adrenal NB removed entirely laparoscopically. Neuroblastoma in the adult population is a rare finding, with worse prognosis compared to pediatric patients. The available literature does not provide enough data for standardized, multimodal management, as the patients are treated following adapted pediatric protocols, thus reinforcing the need for international, multidisciplinary boards for rare tumors. MDPI 2022-12-23 /pmc/articles/PMC9860607/ /pubmed/36676657 http://dx.doi.org/10.3390/medicina59010033 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Telecan, Teodora
Andras, Iulia
Bungardean, Maria Raluca
Muntean, Diana
Militaru, Claudia
Perciuleac, Ion
Maga, Andrei
Crisan, Nicolae
Adrenal Gland Primary Neuroblastoma in an Adult Patient: A Case Report and Literature Review
title Adrenal Gland Primary Neuroblastoma in an Adult Patient: A Case Report and Literature Review
title_full Adrenal Gland Primary Neuroblastoma in an Adult Patient: A Case Report and Literature Review
title_fullStr Adrenal Gland Primary Neuroblastoma in an Adult Patient: A Case Report and Literature Review
title_full_unstemmed Adrenal Gland Primary Neuroblastoma in an Adult Patient: A Case Report and Literature Review
title_short Adrenal Gland Primary Neuroblastoma in an Adult Patient: A Case Report and Literature Review
title_sort adrenal gland primary neuroblastoma in an adult patient: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860607/
https://www.ncbi.nlm.nih.gov/pubmed/36676657
http://dx.doi.org/10.3390/medicina59010033
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