A C57BL/6 Mouse Model of SARS-CoV-2 Infection Recapitulates Age- and Sex-Based Differences in Human COVID-19 Disease and Recovery

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We present a comprehensive analysis of SARS-CoV-2 infection and recovery using wild type C57BL/6 mice and a mouse-adapted virus, and we demonstrate that this is an ideal model of infection and recovery that phenocopies acute human disease arising from the ancestral SARS-CoV-2. Disease severity and i...

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Detalles Bibliográficos
Autores principales: Davis, Michael A., Voss, Kathleen, Turnbull, J. Bryan, Gustin, Andrew T., Knoll, Megan, Muruato, Antonio, Hsiang, Tien-Ying, Dinnon III, Kenneth H., Leist, Sarah R., Nickel, Katie, Baric, Ralph S., Ladiges, Warren, Akilesh, Shreeram, Smith, Kelly D., Gale, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860616/
https://www.ncbi.nlm.nih.gov/pubmed/36679892
http://dx.doi.org/10.3390/vaccines11010047
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