Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids

Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives. 4-Fluoro- and 4-nitrobenzyl-1,2,3-triazole-containing hybrid molecules were prepared. The mono- and bis-coupled hyb...

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Autores principales: Németh-Rieder, Alexandra, Keglevich, Péter, Hunyadi, Attila, Latif, Ahmed Dhahir, Zupkó, István, Hazai, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860848/
https://www.ncbi.nlm.nih.gov/pubmed/36677683
http://dx.doi.org/10.3390/molecules28020626
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author Németh-Rieder, Alexandra
Keglevich, Péter
Hunyadi, Attila
Latif, Ahmed Dhahir
Zupkó, István
Hazai, László
author_facet Németh-Rieder, Alexandra
Keglevich, Péter
Hunyadi, Attila
Latif, Ahmed Dhahir
Zupkó, István
Hazai, László
author_sort Németh-Rieder, Alexandra
collection PubMed
description Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives. 4-Fluoro- and 4-nitrobenzyl-1,2,3-triazole-containing hybrid molecules were prepared. The mono- and bis-coupled hybrids were investigated on 60 cell lines of 9 common cancer types (NCI60) in vitro as antitumor agents. Some of them proved to have a significant antiproliferative effect.
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spelling pubmed-98608482023-01-22 Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids Németh-Rieder, Alexandra Keglevich, Péter Hunyadi, Attila Latif, Ahmed Dhahir Zupkó, István Hazai, László Molecules Article Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives. 4-Fluoro- and 4-nitrobenzyl-1,2,3-triazole-containing hybrid molecules were prepared. The mono- and bis-coupled hybrids were investigated on 60 cell lines of 9 common cancer types (NCI60) in vitro as antitumor agents. Some of them proved to have a significant antiproliferative effect. MDPI 2023-01-07 /pmc/articles/PMC9860848/ /pubmed/36677683 http://dx.doi.org/10.3390/molecules28020626 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Németh-Rieder, Alexandra
Keglevich, Péter
Hunyadi, Attila
Latif, Ahmed Dhahir
Zupkó, István
Hazai, László
Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids
title Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids
title_full Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids
title_fullStr Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids
title_full_unstemmed Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids
title_short Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids
title_sort synthesis and in vitro anticancer evaluation of flavone—1,2,3-triazole hybrids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860848/
https://www.ncbi.nlm.nih.gov/pubmed/36677683
http://dx.doi.org/10.3390/molecules28020626
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