Different Types of Vaccines against Pestiviral Infections: “Barriers” for “Pestis”

The genus Pestivirus of the family Flaviviridae mainly comprises classical swine fever virus (CSFV), bovine viral diarrhea virus 1 (BVDV-1), BVDV-2, border disease virus (BDV), and multiple new pestivirus species such as atypical porcine pestivirus (APPV), giraffe pestivirus, and antelope pestivirus...

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Detalles Bibliográficos
Autores principales: Yuan, Mengqi, Yang, Xiaoke, Zhang, Xin, Zhao, Xiaotian, Abid, Muhammad, Qiu, Hua-Ji, Li, Yongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860862/
https://www.ncbi.nlm.nih.gov/pubmed/36680043
http://dx.doi.org/10.3390/v15010002
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author Yuan, Mengqi
Yang, Xiaoke
Zhang, Xin
Zhao, Xiaotian
Abid, Muhammad
Qiu, Hua-Ji
Li, Yongfeng
author_facet Yuan, Mengqi
Yang, Xiaoke
Zhang, Xin
Zhao, Xiaotian
Abid, Muhammad
Qiu, Hua-Ji
Li, Yongfeng
author_sort Yuan, Mengqi
collection PubMed
description The genus Pestivirus of the family Flaviviridae mainly comprises classical swine fever virus (CSFV), bovine viral diarrhea virus 1 (BVDV-1), BVDV-2, border disease virus (BDV), and multiple new pestivirus species such as atypical porcine pestivirus (APPV), giraffe pestivirus, and antelope pestivirus. Pestiviruses cause infectious diseases, resulting in tremendous economic losses to animal husbandry. Different types of pestivirus vaccines have been developed to control and prevent these important animal diseases. In recent years, pestiviruses have shown great potential as viral vectors for developing multivalent vaccines. This review analyzes the advantages and disadvantages of various pestivirus vaccines, including live attenuated pestivirus strains, genetically engineered marker pestiviruses, and pestivirus-based multivalent vaccines. This review provides new insights into the development of novel vaccines against emerging pestiviruses, such as APPV and ovine pestivirus.
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spelling pubmed-98608622023-01-22 Different Types of Vaccines against Pestiviral Infections: “Barriers” for “Pestis” Yuan, Mengqi Yang, Xiaoke Zhang, Xin Zhao, Xiaotian Abid, Muhammad Qiu, Hua-Ji Li, Yongfeng Viruses Review The genus Pestivirus of the family Flaviviridae mainly comprises classical swine fever virus (CSFV), bovine viral diarrhea virus 1 (BVDV-1), BVDV-2, border disease virus (BDV), and multiple new pestivirus species such as atypical porcine pestivirus (APPV), giraffe pestivirus, and antelope pestivirus. Pestiviruses cause infectious diseases, resulting in tremendous economic losses to animal husbandry. Different types of pestivirus vaccines have been developed to control and prevent these important animal diseases. In recent years, pestiviruses have shown great potential as viral vectors for developing multivalent vaccines. This review analyzes the advantages and disadvantages of various pestivirus vaccines, including live attenuated pestivirus strains, genetically engineered marker pestiviruses, and pestivirus-based multivalent vaccines. This review provides new insights into the development of novel vaccines against emerging pestiviruses, such as APPV and ovine pestivirus. MDPI 2022-12-20 /pmc/articles/PMC9860862/ /pubmed/36680043 http://dx.doi.org/10.3390/v15010002 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yuan, Mengqi
Yang, Xiaoke
Zhang, Xin
Zhao, Xiaotian
Abid, Muhammad
Qiu, Hua-Ji
Li, Yongfeng
Different Types of Vaccines against Pestiviral Infections: “Barriers” for “Pestis”
title Different Types of Vaccines against Pestiviral Infections: “Barriers” for “Pestis”
title_full Different Types of Vaccines against Pestiviral Infections: “Barriers” for “Pestis”
title_fullStr Different Types of Vaccines against Pestiviral Infections: “Barriers” for “Pestis”
title_full_unstemmed Different Types of Vaccines against Pestiviral Infections: “Barriers” for “Pestis”
title_short Different Types of Vaccines against Pestiviral Infections: “Barriers” for “Pestis”
title_sort different types of vaccines against pestiviral infections: “barriers” for “pestis”
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860862/
https://www.ncbi.nlm.nih.gov/pubmed/36680043
http://dx.doi.org/10.3390/v15010002
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