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Selenium-Containing Agents Acting on Cancer—A New Hope?
Selenium-containing agents are more and more considered as an innovative potential treatment option for cancer. Light is shed not only on the considerable advancements made in understanding the complex biology and chemistry related to selenium-containing small molecules but also on Se-nanoparticles....
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860877/ https://www.ncbi.nlm.nih.gov/pubmed/36678733 http://dx.doi.org/10.3390/pharmaceutics15010104 |
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author | Garbo, Sabrina Di Giacomo, Silvia Łażewska, Dorota Honkisz-Orzechowska, Ewelina Di Sotto, Antonella Fioravanti, Rossella Zwergel, Clemens Battistelli, Cecilia |
author_facet | Garbo, Sabrina Di Giacomo, Silvia Łażewska, Dorota Honkisz-Orzechowska, Ewelina Di Sotto, Antonella Fioravanti, Rossella Zwergel, Clemens Battistelli, Cecilia |
author_sort | Garbo, Sabrina |
collection | PubMed |
description | Selenium-containing agents are more and more considered as an innovative potential treatment option for cancer. Light is shed not only on the considerable advancements made in understanding the complex biology and chemistry related to selenium-containing small molecules but also on Se-nanoparticles. Numerous Se-containing agents have been widely investigated in recent years in cancer therapy in relation to tumour development and dissemination, drug delivery, multidrug resistance (MDR) and immune system-related (anti)cancer effects. Despite numerous efforts, Se-agents apart from selenocysteine and selenomethionine have not yet reached clinical trials for cancer therapy. The purpose of this review is to provide a concise critical overview of the current state of the art in the development of highly potent target-specific Se-containing agents. |
format | Online Article Text |
id | pubmed-9860877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98608772023-01-22 Selenium-Containing Agents Acting on Cancer—A New Hope? Garbo, Sabrina Di Giacomo, Silvia Łażewska, Dorota Honkisz-Orzechowska, Ewelina Di Sotto, Antonella Fioravanti, Rossella Zwergel, Clemens Battistelli, Cecilia Pharmaceutics Review Selenium-containing agents are more and more considered as an innovative potential treatment option for cancer. Light is shed not only on the considerable advancements made in understanding the complex biology and chemistry related to selenium-containing small molecules but also on Se-nanoparticles. Numerous Se-containing agents have been widely investigated in recent years in cancer therapy in relation to tumour development and dissemination, drug delivery, multidrug resistance (MDR) and immune system-related (anti)cancer effects. Despite numerous efforts, Se-agents apart from selenocysteine and selenomethionine have not yet reached clinical trials for cancer therapy. The purpose of this review is to provide a concise critical overview of the current state of the art in the development of highly potent target-specific Se-containing agents. MDPI 2022-12-28 /pmc/articles/PMC9860877/ /pubmed/36678733 http://dx.doi.org/10.3390/pharmaceutics15010104 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Garbo, Sabrina Di Giacomo, Silvia Łażewska, Dorota Honkisz-Orzechowska, Ewelina Di Sotto, Antonella Fioravanti, Rossella Zwergel, Clemens Battistelli, Cecilia Selenium-Containing Agents Acting on Cancer—A New Hope? |
title | Selenium-Containing Agents Acting on Cancer—A New Hope? |
title_full | Selenium-Containing Agents Acting on Cancer—A New Hope? |
title_fullStr | Selenium-Containing Agents Acting on Cancer—A New Hope? |
title_full_unstemmed | Selenium-Containing Agents Acting on Cancer—A New Hope? |
title_short | Selenium-Containing Agents Acting on Cancer—A New Hope? |
title_sort | selenium-containing agents acting on cancer—a new hope? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860877/ https://www.ncbi.nlm.nih.gov/pubmed/36678733 http://dx.doi.org/10.3390/pharmaceutics15010104 |
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