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Effect of the Marine Polyketide Plocabulin on Tumor Progression
Marine sponges represent one of the richest sources of natural marine compounds with anticancer potential. Plocabulin (PM060184), a polyketide originally isolated from the sponge Lithoplocamia lithistoides, elicits its main anticancer properties binding tubulin, which still represents one of the mos...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860935/ https://www.ncbi.nlm.nih.gov/pubmed/36662211 http://dx.doi.org/10.3390/md21010038 |
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author | Turrini, Eleonora Maffei, Francesca Fimognari, Carmela |
author_facet | Turrini, Eleonora Maffei, Francesca Fimognari, Carmela |
author_sort | Turrini, Eleonora |
collection | PubMed |
description | Marine sponges represent one of the richest sources of natural marine compounds with anticancer potential. Plocabulin (PM060184), a polyketide originally isolated from the sponge Lithoplocamia lithistoides, elicits its main anticancer properties binding tubulin, which still represents one of the most important targets for anticancer drugs. Plocabulin showed potent antitumor activity, in both in vitro and in vivo models of different types of cancers, mediated not only by its antitubulin activity, but also by its ability to block endothelial cell migration and invasion. The objective of this review is to offer a description of plocabulin’s mechanisms of action, with special emphasis on the antiangiogenic signals and the latest progress on its development as an anticancer agent. |
format | Online Article Text |
id | pubmed-9860935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98609352023-01-22 Effect of the Marine Polyketide Plocabulin on Tumor Progression Turrini, Eleonora Maffei, Francesca Fimognari, Carmela Mar Drugs Review Marine sponges represent one of the richest sources of natural marine compounds with anticancer potential. Plocabulin (PM060184), a polyketide originally isolated from the sponge Lithoplocamia lithistoides, elicits its main anticancer properties binding tubulin, which still represents one of the most important targets for anticancer drugs. Plocabulin showed potent antitumor activity, in both in vitro and in vivo models of different types of cancers, mediated not only by its antitubulin activity, but also by its ability to block endothelial cell migration and invasion. The objective of this review is to offer a description of plocabulin’s mechanisms of action, with special emphasis on the antiangiogenic signals and the latest progress on its development as an anticancer agent. MDPI 2022-12-31 /pmc/articles/PMC9860935/ /pubmed/36662211 http://dx.doi.org/10.3390/md21010038 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Turrini, Eleonora Maffei, Francesca Fimognari, Carmela Effect of the Marine Polyketide Plocabulin on Tumor Progression |
title | Effect of the Marine Polyketide Plocabulin on Tumor Progression |
title_full | Effect of the Marine Polyketide Plocabulin on Tumor Progression |
title_fullStr | Effect of the Marine Polyketide Plocabulin on Tumor Progression |
title_full_unstemmed | Effect of the Marine Polyketide Plocabulin on Tumor Progression |
title_short | Effect of the Marine Polyketide Plocabulin on Tumor Progression |
title_sort | effect of the marine polyketide plocabulin on tumor progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860935/ https://www.ncbi.nlm.nih.gov/pubmed/36662211 http://dx.doi.org/10.3390/md21010038 |
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