Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis

Marine microorganisms are an important source of natural polyketides, which have become a significant reservoir of lead structures for drug design due to their diverse biological activities. In this review, we provide a summary of the resources, structures, biological activities, and proposed biosyn...

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Autores principales: Štiblariková, Mária, Lásiková, Angelika, Gracza, Tibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860963/
https://www.ncbi.nlm.nih.gov/pubmed/36662192
http://dx.doi.org/10.3390/md21010019
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author Štiblariková, Mária
Lásiková, Angelika
Gracza, Tibor
author_facet Štiblariková, Mária
Lásiková, Angelika
Gracza, Tibor
author_sort Štiblariková, Mária
collection PubMed
description Marine microorganisms are an important source of natural polyketides, which have become a significant reservoir of lead structures for drug design due to their diverse biological activities. In this review, we provide a summary of the resources, structures, biological activities, and proposed biosynthetic pathways of the benzyl alcohol/salicylaldehyde-type polyketides. In addition, the total syntheses of these secondary metabolites from their discoveries to the present day are presented. This review could be helpful for researchers in the total synthesis of complex natural products and the use of polyketide bioactive molecules for pharmacological purposes and applications in medicinal chemistry.
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spelling pubmed-98609632023-01-22 Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis Štiblariková, Mária Lásiková, Angelika Gracza, Tibor Mar Drugs Review Marine microorganisms are an important source of natural polyketides, which have become a significant reservoir of lead structures for drug design due to their diverse biological activities. In this review, we provide a summary of the resources, structures, biological activities, and proposed biosynthetic pathways of the benzyl alcohol/salicylaldehyde-type polyketides. In addition, the total syntheses of these secondary metabolites from their discoveries to the present day are presented. This review could be helpful for researchers in the total synthesis of complex natural products and the use of polyketide bioactive molecules for pharmacological purposes and applications in medicinal chemistry. MDPI 2022-12-27 /pmc/articles/PMC9860963/ /pubmed/36662192 http://dx.doi.org/10.3390/md21010019 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Štiblariková, Mária
Lásiková, Angelika
Gracza, Tibor
Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis
title Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis
title_full Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis
title_fullStr Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis
title_full_unstemmed Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis
title_short Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis
title_sort benzyl alcohol/salicylaldehyde-type polyketide metabolites of fungi: sources, biosynthesis, biological activities, and synthesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860963/
https://www.ncbi.nlm.nih.gov/pubmed/36662192
http://dx.doi.org/10.3390/md21010019
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AT graczatibor benzylalcoholsalicylaldehydetypepolyketidemetabolitesoffungisourcesbiosynthesisbiologicalactivitiesandsynthesis

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