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Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer
Various species of non-coding RNAs (ncRNAs) may act as functional molecules regulating diverse biological processes. In cancer cell biology, ncRNAs include RNAs that regulate the expression of oncogenes and tumor suppressor genes through various mechanisms. The urokinase (uPA)-mediated plasminogen a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860977/ https://www.ncbi.nlm.nih.gov/pubmed/36674481 http://dx.doi.org/10.3390/ijms24020962 |
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author | Alfieri, Mariaevelina Meo, Luigia Ragno, Pia |
author_facet | Alfieri, Mariaevelina Meo, Luigia Ragno, Pia |
author_sort | Alfieri, Mariaevelina |
collection | PubMed |
description | Various species of non-coding RNAs (ncRNAs) may act as functional molecules regulating diverse biological processes. In cancer cell biology, ncRNAs include RNAs that regulate the expression of oncogenes and tumor suppressor genes through various mechanisms. The urokinase (uPA)-mediated plasminogen activation system (PAS) includes uPA, its inhibitors PAI-1 and PAI-2 and its specific cellular receptor uPAR; their increased expression represents a negative prognostic factor in several cancers. Here, we will briefly describe the main uPA-mediated PAS components and ncRNA species; then, we will review more recent evidence of the roles that ncRNAs may play in regulating the expression and functions of uPA-mediated PAS components in cancer. |
format | Online Article Text |
id | pubmed-9860977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98609772023-01-22 Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer Alfieri, Mariaevelina Meo, Luigia Ragno, Pia Int J Mol Sci Review Various species of non-coding RNAs (ncRNAs) may act as functional molecules regulating diverse biological processes. In cancer cell biology, ncRNAs include RNAs that regulate the expression of oncogenes and tumor suppressor genes through various mechanisms. The urokinase (uPA)-mediated plasminogen activation system (PAS) includes uPA, its inhibitors PAI-1 and PAI-2 and its specific cellular receptor uPAR; their increased expression represents a negative prognostic factor in several cancers. Here, we will briefly describe the main uPA-mediated PAS components and ncRNA species; then, we will review more recent evidence of the roles that ncRNAs may play in regulating the expression and functions of uPA-mediated PAS components in cancer. MDPI 2023-01-04 /pmc/articles/PMC9860977/ /pubmed/36674481 http://dx.doi.org/10.3390/ijms24020962 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Alfieri, Mariaevelina Meo, Luigia Ragno, Pia Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer |
title | Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer |
title_full | Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer |
title_fullStr | Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer |
title_full_unstemmed | Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer |
title_short | Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer |
title_sort | posttranscriptional regulation of the plasminogen activation system by non-coding rna in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860977/ https://www.ncbi.nlm.nih.gov/pubmed/36674481 http://dx.doi.org/10.3390/ijms24020962 |
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