Cargando…

Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer

Various species of non-coding RNAs (ncRNAs) may act as functional molecules regulating diverse biological processes. In cancer cell biology, ncRNAs include RNAs that regulate the expression of oncogenes and tumor suppressor genes through various mechanisms. The urokinase (uPA)-mediated plasminogen a...

Descripción completa

Detalles Bibliográficos
Autores principales: Alfieri, Mariaevelina, Meo, Luigia, Ragno, Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860977/
https://www.ncbi.nlm.nih.gov/pubmed/36674481
http://dx.doi.org/10.3390/ijms24020962
_version_ 1784874726074613760
author Alfieri, Mariaevelina
Meo, Luigia
Ragno, Pia
author_facet Alfieri, Mariaevelina
Meo, Luigia
Ragno, Pia
author_sort Alfieri, Mariaevelina
collection PubMed
description Various species of non-coding RNAs (ncRNAs) may act as functional molecules regulating diverse biological processes. In cancer cell biology, ncRNAs include RNAs that regulate the expression of oncogenes and tumor suppressor genes through various mechanisms. The urokinase (uPA)-mediated plasminogen activation system (PAS) includes uPA, its inhibitors PAI-1 and PAI-2 and its specific cellular receptor uPAR; their increased expression represents a negative prognostic factor in several cancers. Here, we will briefly describe the main uPA-mediated PAS components and ncRNA species; then, we will review more recent evidence of the roles that ncRNAs may play in regulating the expression and functions of uPA-mediated PAS components in cancer.
format Online
Article
Text
id pubmed-9860977
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98609772023-01-22 Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer Alfieri, Mariaevelina Meo, Luigia Ragno, Pia Int J Mol Sci Review Various species of non-coding RNAs (ncRNAs) may act as functional molecules regulating diverse biological processes. In cancer cell biology, ncRNAs include RNAs that regulate the expression of oncogenes and tumor suppressor genes through various mechanisms. The urokinase (uPA)-mediated plasminogen activation system (PAS) includes uPA, its inhibitors PAI-1 and PAI-2 and its specific cellular receptor uPAR; their increased expression represents a negative prognostic factor in several cancers. Here, we will briefly describe the main uPA-mediated PAS components and ncRNA species; then, we will review more recent evidence of the roles that ncRNAs may play in regulating the expression and functions of uPA-mediated PAS components in cancer. MDPI 2023-01-04 /pmc/articles/PMC9860977/ /pubmed/36674481 http://dx.doi.org/10.3390/ijms24020962 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alfieri, Mariaevelina
Meo, Luigia
Ragno, Pia
Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer
title Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer
title_full Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer
title_fullStr Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer
title_full_unstemmed Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer
title_short Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer
title_sort posttranscriptional regulation of the plasminogen activation system by non-coding rna in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860977/
https://www.ncbi.nlm.nih.gov/pubmed/36674481
http://dx.doi.org/10.3390/ijms24020962
work_keys_str_mv AT alfierimariaevelina posttranscriptionalregulationoftheplasminogenactivationsystembynoncodingrnaincancer
AT meoluigia posttranscriptionalregulationoftheplasminogenactivationsystembynoncodingrnaincancer
AT ragnopia posttranscriptionalregulationoftheplasminogenactivationsystembynoncodingrnaincancer