Two-Step Targeted Drug Delivery via Proteinaceous Barnase-Barstar Interface and Doxorubicin-Loaded Nano-PLGA Outperforms One-Step Strategy for Targeted Delivery to HER2-Overexpressing Cells

Nanoparticle-based chemotherapy is considered to be an effective approach to cancer diagnostics and therapy in modern biomedicine. However, efficient tumor targeting remains a great challenge due to the lack of specificity, selectivity, and high dosage of chemotherapeutic drugs required. A two-step...

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Detalles Bibliográficos
Autores principales: Komedchikova, Elena N., Kolesnikova, Olga A., Tereshina, Ekaterina D., Kotelnikova, Polina A., Sogomonyan, Anna S., Stepanov, Alexey V., Deyev, Sergey M., Nikitin, Maxim P., Shipunova, Victoria O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861000/
https://www.ncbi.nlm.nih.gov/pubmed/36678681
http://dx.doi.org/10.3390/pharmaceutics15010052

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