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Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort
The genetic polymorphisms rs2395185 and rs2097432 in HLA genes have been associated with the response to anti-TNF treatment in inflammatory bowel disease (IBD). The aim was to analyze the association between these variants and the long-term response to anti-TNF drugs in pediatric IBD. We performed a...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861004/ https://www.ncbi.nlm.nih.gov/pubmed/36675312 http://dx.doi.org/10.3390/ijms24021797 |
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author | Salvador-Martín, Sara Zapata-Cobo, Paula Velasco, Marta Palomino, Laura M. Clemente, Susana Segarra, Oscar Sánchez, Cesar Tolín, Mar Moreno-Álvarez, Ana Fernández-Lorenzo, Ana Pérez-Moneo, Begoña Loverdos, Inés Navas López, Victor Manuel Millán, Antonio Magallares, Lorena Torres-Peral, Ricardo García-Romero, Ruth Pujol-Muncunill, Gemma Merino-Bohorquez, Vicente Rodríguez, Alejandro Salcedo, Enrique López-Cauce, Beatriz Marín-Jiménez, Ignacio Menchén, Luis Laserna-Mendieta, Emilio Lucendo, Alfredo J. Sanjurjo-Sáez, María López-Fernández, Luis A. |
author_facet | Salvador-Martín, Sara Zapata-Cobo, Paula Velasco, Marta Palomino, Laura M. Clemente, Susana Segarra, Oscar Sánchez, Cesar Tolín, Mar Moreno-Álvarez, Ana Fernández-Lorenzo, Ana Pérez-Moneo, Begoña Loverdos, Inés Navas López, Victor Manuel Millán, Antonio Magallares, Lorena Torres-Peral, Ricardo García-Romero, Ruth Pujol-Muncunill, Gemma Merino-Bohorquez, Vicente Rodríguez, Alejandro Salcedo, Enrique López-Cauce, Beatriz Marín-Jiménez, Ignacio Menchén, Luis Laserna-Mendieta, Emilio Lucendo, Alfredo J. Sanjurjo-Sáez, María López-Fernández, Luis A. |
author_sort | Salvador-Martín, Sara |
collection | PubMed |
description | The genetic polymorphisms rs2395185 and rs2097432 in HLA genes have been associated with the response to anti-TNF treatment in inflammatory bowel disease (IBD). The aim was to analyze the association between these variants and the long-term response to anti-TNF drugs in pediatric IBD. We performed an observational, multicenter, ambispective study in which we selected 340 IBD patients under 18 years of age diagnosed with IBD and treated with anti-TNF drugs from a network of Spanish hospitals. Genotypes and failure of anti-TNF drugs were analyzed using Kaplan-Meier curves and Cox logistic regression. The homozygous G allele of rs2395185 and the C allele of rs2097432 were associated with impaired long-term response to anti-TNF drugs in children with IBD after 3 and 9 years of follow-up. Being a carrier of both polymorphisms increased the risk of anti-TNF failure. The SNP rs2395185 but not rs2097432 was associated with response to infliximab in adults with CD treated with infliximab but not in children after 3 or 9 years of follow-up. Conclusions: SNPs rs2395185 and rs2097432 were associated with a long-term response to anti-TNFs in IBD in Spanish children. Differences between adults and children were observed in patients diagnosed with CD and treated with infliximab. |
format | Online Article Text |
id | pubmed-9861004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98610042023-01-22 Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort Salvador-Martín, Sara Zapata-Cobo, Paula Velasco, Marta Palomino, Laura M. Clemente, Susana Segarra, Oscar Sánchez, Cesar Tolín, Mar Moreno-Álvarez, Ana Fernández-Lorenzo, Ana Pérez-Moneo, Begoña Loverdos, Inés Navas López, Victor Manuel Millán, Antonio Magallares, Lorena Torres-Peral, Ricardo García-Romero, Ruth Pujol-Muncunill, Gemma Merino-Bohorquez, Vicente Rodríguez, Alejandro Salcedo, Enrique López-Cauce, Beatriz Marín-Jiménez, Ignacio Menchén, Luis Laserna-Mendieta, Emilio Lucendo, Alfredo J. Sanjurjo-Sáez, María López-Fernández, Luis A. Int J Mol Sci Article The genetic polymorphisms rs2395185 and rs2097432 in HLA genes have been associated with the response to anti-TNF treatment in inflammatory bowel disease (IBD). The aim was to analyze the association between these variants and the long-term response to anti-TNF drugs in pediatric IBD. We performed an observational, multicenter, ambispective study in which we selected 340 IBD patients under 18 years of age diagnosed with IBD and treated with anti-TNF drugs from a network of Spanish hospitals. Genotypes and failure of anti-TNF drugs were analyzed using Kaplan-Meier curves and Cox logistic regression. The homozygous G allele of rs2395185 and the C allele of rs2097432 were associated with impaired long-term response to anti-TNF drugs in children with IBD after 3 and 9 years of follow-up. Being a carrier of both polymorphisms increased the risk of anti-TNF failure. The SNP rs2395185 but not rs2097432 was associated with response to infliximab in adults with CD treated with infliximab but not in children after 3 or 9 years of follow-up. Conclusions: SNPs rs2395185 and rs2097432 were associated with a long-term response to anti-TNFs in IBD in Spanish children. Differences between adults and children were observed in patients diagnosed with CD and treated with infliximab. MDPI 2023-01-16 /pmc/articles/PMC9861004/ /pubmed/36675312 http://dx.doi.org/10.3390/ijms24021797 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Salvador-Martín, Sara Zapata-Cobo, Paula Velasco, Marta Palomino, Laura M. Clemente, Susana Segarra, Oscar Sánchez, Cesar Tolín, Mar Moreno-Álvarez, Ana Fernández-Lorenzo, Ana Pérez-Moneo, Begoña Loverdos, Inés Navas López, Victor Manuel Millán, Antonio Magallares, Lorena Torres-Peral, Ricardo García-Romero, Ruth Pujol-Muncunill, Gemma Merino-Bohorquez, Vicente Rodríguez, Alejandro Salcedo, Enrique López-Cauce, Beatriz Marín-Jiménez, Ignacio Menchén, Luis Laserna-Mendieta, Emilio Lucendo, Alfredo J. Sanjurjo-Sáez, María López-Fernández, Luis A. Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort |
title | Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort |
title_full | Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort |
title_fullStr | Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort |
title_full_unstemmed | Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort |
title_short | Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort |
title_sort | association between hla dna variants and long-term response to anti-tnf drugs in a spanish pediatric inflammatory bowel disease cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861004/ https://www.ncbi.nlm.nih.gov/pubmed/36675312 http://dx.doi.org/10.3390/ijms24021797 |
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