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Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering

In this review, we aim to provide a summary of recent research advancements and applications of algin (i.e., alginic acid) and alginate-hybrid materials (AHMs) in medical fields. Algin/alginate are abundant natural products that are chemically inert and biocompatible, and they have superior gelation...

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Detalles Bibliográficos
Autores principales: He, Qing, Tong, Tianjian, Yu, Chenxu, Wang, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861007/
https://www.ncbi.nlm.nih.gov/pubmed/36662187
http://dx.doi.org/10.3390/md21010014
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author He, Qing
Tong, Tianjian
Yu, Chenxu
Wang, Qun
author_facet He, Qing
Tong, Tianjian
Yu, Chenxu
Wang, Qun
author_sort He, Qing
collection PubMed
description In this review, we aim to provide a summary of recent research advancements and applications of algin (i.e., alginic acid) and alginate-hybrid materials (AHMs) in medical fields. Algin/alginate are abundant natural products that are chemically inert and biocompatible, and they have superior gelation properties, good mechanical strengths, and biodegradability. The AHMs have been widely applied in wound dressing, cell culture, tissue engineering, and drug delivery. However, medical applications in different fields require different properties in the AHMs. The drug delivery application requires AHMs to provide optimal drug loading, controlled and targeted drug-releasing, and/or visually guided drug delivery. AHMs for wound dressing application need to have improved mechanical properties, hydrophilicity, cell adhesion, and antibacterial properties. AHMs for tissue engineering need improved mechanical properties that match the target organs, superior cell affinity, and cell loading capacity. Various methods to produce AHMs that meet different needs were summarized. Formulations to form AHMs with improved stability, drug/cell-loading capacity, cell adhesion, and mechanical properties are active research areas. This review serves as a road map to provide insights into the strategies to develop AHMs in medical applications.
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spelling pubmed-98610072023-01-22 Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering He, Qing Tong, Tianjian Yu, Chenxu Wang, Qun Mar Drugs Review In this review, we aim to provide a summary of recent research advancements and applications of algin (i.e., alginic acid) and alginate-hybrid materials (AHMs) in medical fields. Algin/alginate are abundant natural products that are chemically inert and biocompatible, and they have superior gelation properties, good mechanical strengths, and biodegradability. The AHMs have been widely applied in wound dressing, cell culture, tissue engineering, and drug delivery. However, medical applications in different fields require different properties in the AHMs. The drug delivery application requires AHMs to provide optimal drug loading, controlled and targeted drug-releasing, and/or visually guided drug delivery. AHMs for wound dressing application need to have improved mechanical properties, hydrophilicity, cell adhesion, and antibacterial properties. AHMs for tissue engineering need improved mechanical properties that match the target organs, superior cell affinity, and cell loading capacity. Various methods to produce AHMs that meet different needs were summarized. Formulations to form AHMs with improved stability, drug/cell-loading capacity, cell adhesion, and mechanical properties are active research areas. This review serves as a road map to provide insights into the strategies to develop AHMs in medical applications. MDPI 2022-12-24 /pmc/articles/PMC9861007/ /pubmed/36662187 http://dx.doi.org/10.3390/md21010014 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
He, Qing
Tong, Tianjian
Yu, Chenxu
Wang, Qun
Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering
title Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering
title_full Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering
title_fullStr Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering
title_full_unstemmed Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering
title_short Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering
title_sort advances in algin and alginate-hybrid materials for drug delivery and tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861007/
https://www.ncbi.nlm.nih.gov/pubmed/36662187
http://dx.doi.org/10.3390/md21010014
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