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Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering
In this review, we aim to provide a summary of recent research advancements and applications of algin (i.e., alginic acid) and alginate-hybrid materials (AHMs) in medical fields. Algin/alginate are abundant natural products that are chemically inert and biocompatible, and they have superior gelation...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861007/ https://www.ncbi.nlm.nih.gov/pubmed/36662187 http://dx.doi.org/10.3390/md21010014 |
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author | He, Qing Tong, Tianjian Yu, Chenxu Wang, Qun |
author_facet | He, Qing Tong, Tianjian Yu, Chenxu Wang, Qun |
author_sort | He, Qing |
collection | PubMed |
description | In this review, we aim to provide a summary of recent research advancements and applications of algin (i.e., alginic acid) and alginate-hybrid materials (AHMs) in medical fields. Algin/alginate are abundant natural products that are chemically inert and biocompatible, and they have superior gelation properties, good mechanical strengths, and biodegradability. The AHMs have been widely applied in wound dressing, cell culture, tissue engineering, and drug delivery. However, medical applications in different fields require different properties in the AHMs. The drug delivery application requires AHMs to provide optimal drug loading, controlled and targeted drug-releasing, and/or visually guided drug delivery. AHMs for wound dressing application need to have improved mechanical properties, hydrophilicity, cell adhesion, and antibacterial properties. AHMs for tissue engineering need improved mechanical properties that match the target organs, superior cell affinity, and cell loading capacity. Various methods to produce AHMs that meet different needs were summarized. Formulations to form AHMs with improved stability, drug/cell-loading capacity, cell adhesion, and mechanical properties are active research areas. This review serves as a road map to provide insights into the strategies to develop AHMs in medical applications. |
format | Online Article Text |
id | pubmed-9861007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98610072023-01-22 Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering He, Qing Tong, Tianjian Yu, Chenxu Wang, Qun Mar Drugs Review In this review, we aim to provide a summary of recent research advancements and applications of algin (i.e., alginic acid) and alginate-hybrid materials (AHMs) in medical fields. Algin/alginate are abundant natural products that are chemically inert and biocompatible, and they have superior gelation properties, good mechanical strengths, and biodegradability. The AHMs have been widely applied in wound dressing, cell culture, tissue engineering, and drug delivery. However, medical applications in different fields require different properties in the AHMs. The drug delivery application requires AHMs to provide optimal drug loading, controlled and targeted drug-releasing, and/or visually guided drug delivery. AHMs for wound dressing application need to have improved mechanical properties, hydrophilicity, cell adhesion, and antibacterial properties. AHMs for tissue engineering need improved mechanical properties that match the target organs, superior cell affinity, and cell loading capacity. Various methods to produce AHMs that meet different needs were summarized. Formulations to form AHMs with improved stability, drug/cell-loading capacity, cell adhesion, and mechanical properties are active research areas. This review serves as a road map to provide insights into the strategies to develop AHMs in medical applications. MDPI 2022-12-24 /pmc/articles/PMC9861007/ /pubmed/36662187 http://dx.doi.org/10.3390/md21010014 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review He, Qing Tong, Tianjian Yu, Chenxu Wang, Qun Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering |
title | Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering |
title_full | Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering |
title_fullStr | Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering |
title_full_unstemmed | Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering |
title_short | Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering |
title_sort | advances in algin and alginate-hybrid materials for drug delivery and tissue engineering |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861007/ https://www.ncbi.nlm.nih.gov/pubmed/36662187 http://dx.doi.org/10.3390/md21010014 |
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