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COVID-19 Vaccination Is Not Associated with Psychiatric Adverse Events: A Meta-Analysis
Coronavirus disease 2019 (COVID-19) has been a global health problem since December 2019. Vaccination has been widely considered the best way to prevent COVID-19 pandemic, but public concerns about the safety of vaccines remain. There have been many studies reporting adverse events in the vaccinated...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861090/ https://www.ncbi.nlm.nih.gov/pubmed/36680038 http://dx.doi.org/10.3390/vaccines11010194 |
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author | Lee, Sang-Eun Shim, Sung-Ryul Youn, Jung-Hae Han, Hyun-Wook |
author_facet | Lee, Sang-Eun Shim, Sung-Ryul Youn, Jung-Hae Han, Hyun-Wook |
author_sort | Lee, Sang-Eun |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) has been a global health problem since December 2019. Vaccination has been widely considered the best way to prevent COVID-19 pandemic, but public concerns about the safety of vaccines remain. There have been many studies reporting adverse events in the vaccinated. However, to date, no meta-analysis of the association of COVID-19 vaccination with psychiatric adverse events has been conducted yet. In this meta-analysis, studies on depression, anxiety and distress after COVID-19 vaccination were searched in the PubMed, Cochrane and Embase from January 2020 to April 2022. The OR of depression in four studies with a total sample size of 462,406 is obtained as 0.88 (95% CI; 0.75, 1.03), and the OR of anxiety as 0.86 (95% CI; 0.71, 1.05). However, there were no statistically significant differences between the groups. The mean difference of distress in two studies was −0.04 (95%CI; −0.05, −0.02; p < 0.0001). As a result of the moderator analysis, married people experienced less depression and anxiety after vaccination, and in White people, depression after vaccination was lower than others. We also found that people with a history of COVID-19 infection were more depressed and anxious after vaccination. We suggest that COVID-19 vaccination was not associated with a worsening of depression and anxiety. |
format | Online Article Text |
id | pubmed-9861090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98610902023-01-22 COVID-19 Vaccination Is Not Associated with Psychiatric Adverse Events: A Meta-Analysis Lee, Sang-Eun Shim, Sung-Ryul Youn, Jung-Hae Han, Hyun-Wook Vaccines (Basel) Systematic Review Coronavirus disease 2019 (COVID-19) has been a global health problem since December 2019. Vaccination has been widely considered the best way to prevent COVID-19 pandemic, but public concerns about the safety of vaccines remain. There have been many studies reporting adverse events in the vaccinated. However, to date, no meta-analysis of the association of COVID-19 vaccination with psychiatric adverse events has been conducted yet. In this meta-analysis, studies on depression, anxiety and distress after COVID-19 vaccination were searched in the PubMed, Cochrane and Embase from January 2020 to April 2022. The OR of depression in four studies with a total sample size of 462,406 is obtained as 0.88 (95% CI; 0.75, 1.03), and the OR of anxiety as 0.86 (95% CI; 0.71, 1.05). However, there were no statistically significant differences between the groups. The mean difference of distress in two studies was −0.04 (95%CI; −0.05, −0.02; p < 0.0001). As a result of the moderator analysis, married people experienced less depression and anxiety after vaccination, and in White people, depression after vaccination was lower than others. We also found that people with a history of COVID-19 infection were more depressed and anxious after vaccination. We suggest that COVID-19 vaccination was not associated with a worsening of depression and anxiety. MDPI 2023-01-16 /pmc/articles/PMC9861090/ /pubmed/36680038 http://dx.doi.org/10.3390/vaccines11010194 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Lee, Sang-Eun Shim, Sung-Ryul Youn, Jung-Hae Han, Hyun-Wook COVID-19 Vaccination Is Not Associated with Psychiatric Adverse Events: A Meta-Analysis |
title | COVID-19 Vaccination Is Not Associated with Psychiatric Adverse Events: A Meta-Analysis |
title_full | COVID-19 Vaccination Is Not Associated with Psychiatric Adverse Events: A Meta-Analysis |
title_fullStr | COVID-19 Vaccination Is Not Associated with Psychiatric Adverse Events: A Meta-Analysis |
title_full_unstemmed | COVID-19 Vaccination Is Not Associated with Psychiatric Adverse Events: A Meta-Analysis |
title_short | COVID-19 Vaccination Is Not Associated with Psychiatric Adverse Events: A Meta-Analysis |
title_sort | covid-19 vaccination is not associated with psychiatric adverse events: a meta-analysis |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861090/ https://www.ncbi.nlm.nih.gov/pubmed/36680038 http://dx.doi.org/10.3390/vaccines11010194 |
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