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A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease

Neurodegenerative diseases occur due to progressive and sometimes irreversible loss of function and death of nerve cells. A great deal of effort is being made to understand the pathogenesis of neurodegenerative diseases. In particular, the prevalence of Alzheimer’s disease (AD) is quite high, and on...

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Autores principales: Sahiner, Mehtap, Yilmaz, Aynur Sanem, Gungor, Buket, Sahiner, Nurettin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861153/
https://www.ncbi.nlm.nih.gov/pubmed/36662097
http://dx.doi.org/10.3390/jfb14010050
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author Sahiner, Mehtap
Yilmaz, Aynur Sanem
Gungor, Buket
Sahiner, Nurettin
author_facet Sahiner, Mehtap
Yilmaz, Aynur Sanem
Gungor, Buket
Sahiner, Nurettin
author_sort Sahiner, Mehtap
collection PubMed
description Neurodegenerative diseases occur due to progressive and sometimes irreversible loss of function and death of nerve cells. A great deal of effort is being made to understand the pathogenesis of neurodegenerative diseases. In particular, the prevalence of Alzheimer’s disease (AD) is quite high, and only symptomatic therapy is available due to the absence of radical treatment. The aim of this review is to try to elucidate the general pathogenesis of AD, to provide information about the limit points of symptomatic treatment approaches, and to emphasize the potential neurologic effects of phytocompounds as new tools as therapeutic agents for disease prevention, retardation, and therapy. This survey also covers the notable properties of herbal compounds such as their effects on the inhibition of an enzyme called acetylcholinesterase, which has significant value in the treatment of AD. It has been proven that phytopharmaceuticals have long-term effects that could protect nervous system health, eliminate inflammatory responses, improve cognitive damage, provide anti-aging effects in the natural aging process, and alleviate dementia sequelae. Herbal-based therapeutic agents can afford many advantages and can be used as potentially as new-generation therapeutics or complementary agents with high compliance, fewer adverse effects, and lower cost in comparison to the traditional pharmaceutical agents in the fight against AD.
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spelling pubmed-98611532023-01-22 A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease Sahiner, Mehtap Yilmaz, Aynur Sanem Gungor, Buket Sahiner, Nurettin J Funct Biomater Review Neurodegenerative diseases occur due to progressive and sometimes irreversible loss of function and death of nerve cells. A great deal of effort is being made to understand the pathogenesis of neurodegenerative diseases. In particular, the prevalence of Alzheimer’s disease (AD) is quite high, and only symptomatic therapy is available due to the absence of radical treatment. The aim of this review is to try to elucidate the general pathogenesis of AD, to provide information about the limit points of symptomatic treatment approaches, and to emphasize the potential neurologic effects of phytocompounds as new tools as therapeutic agents for disease prevention, retardation, and therapy. This survey also covers the notable properties of herbal compounds such as their effects on the inhibition of an enzyme called acetylcholinesterase, which has significant value in the treatment of AD. It has been proven that phytopharmaceuticals have long-term effects that could protect nervous system health, eliminate inflammatory responses, improve cognitive damage, provide anti-aging effects in the natural aging process, and alleviate dementia sequelae. Herbal-based therapeutic agents can afford many advantages and can be used as potentially as new-generation therapeutics or complementary agents with high compliance, fewer adverse effects, and lower cost in comparison to the traditional pharmaceutical agents in the fight against AD. MDPI 2023-01-16 /pmc/articles/PMC9861153/ /pubmed/36662097 http://dx.doi.org/10.3390/jfb14010050 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sahiner, Mehtap
Yilmaz, Aynur Sanem
Gungor, Buket
Sahiner, Nurettin
A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease
title A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease
title_full A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease
title_fullStr A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease
title_full_unstemmed A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease
title_short A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease
title_sort review on phyto-therapeutic approaches in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861153/
https://www.ncbi.nlm.nih.gov/pubmed/36662097
http://dx.doi.org/10.3390/jfb14010050
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